Adjunctive probiotics after periodontal debridement versus placebo: a systematic review and meta-analysis.
Autor: | Ng E; Discipline of Periodontics, Faculty of Dentistry, National University of Singapore, Singapore.; Department of Restorative Dentistry, National Dental Centre Singapore, Singapore., Tay JRH; Discipline of Periodontics, Faculty of Dentistry, National University of Singapore, Singapore.; Department of Restorative Dentistry, National Dental Centre Singapore, Singapore., Saffari SE; Health Services and Systems Research, Duke-NUS Medical School, Singapore., Lim LP; Discipline of Periodontics, Faculty of Dentistry, National University of Singapore, Singapore., Chung KM; Discipline of Periodontics, Faculty of Dentistry, National University of Singapore, Singapore., Ong MMA; Department of Restorative Dentistry, National Dental Centre Singapore, Singapore.; Oral Health Academic Clinical Programme, Duke-NUS Medical School, Singapore. |
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Jazyk: | angličtina |
Zdroj: | Acta odontologica Scandinavica [Acta Odontol Scand] 2022 Mar; Vol. 80 (2), pp. 81-90. Date of Electronic Publication: 2021 Jul 01. |
DOI: | 10.1080/00016357.2021.1942193 |
Abstrakt: | Objective: To comprehensively investigate the efficacy of adjunctive probiotics compared to placebo, using conventional and novel treatment outcomes. Materials and Methods: Three databases (MEDLINE, EMBASE, and CENTRAL) were searched. Outcomes included percent change in the total number of deep sites before and after therapy, change in mean probing pocket depth (mm), percentage patients requiring additional therapy, risk for disease progression, and microbiological and immunological results. Meta-analysis was conducted to evaluate treatment effects wherever appropriate. Results: Ten studies were selected from 818 records. Meta-analysis showed that adjunctive probiotics had no additional benefit for percentage change of the total number of deeper sites (≥5 mm, ≥6 mm, ≥7 mm) before and after therapy. No significant difference was observed for mean probing pocket depth reduction at 3 and 6 months. Statistically significant beneficial odds ratios for need for additional therapy (OR = 0.19, 95% CI [0.07-0.56]) and risk of disease progression (OR = 0.32, 95% CI [0.14-0.73]) were observed with probiotic administration. Immunological rather than microbiological outcomes correlated more consistently with clinical findings. No adverse events were reported. Conclusions: Adjunctive probiotics are safe in systemically healthy individuals and could offer additional patient-level benefits compared to placebo, hence its use can sometimes be justified. |
Databáze: | MEDLINE |
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