Effects of dipyrone and acetylsalicylic acid on contractions of distal cauda epididymis duct, serum testosterone and sperm count in rats.

Autor: Martins ABM; Mode of Drug Action Laboratory, Federal University of Rio Grande do Norte, Natal, Brazil., Bezerra MS; Mode of Drug Action Laboratory, Federal University of Rio Grande do Norte, Natal, Brazil., da Costa Gomes LT; Mode of Drug Action Laboratory, Federal University of Rio Grande do Norte, Natal, Brazil., Trajano FMG; Mode of Drug Action Laboratory, Federal University of Rio Grande do Norte, Natal, Brazil., Dantas PB; Mode of Drug Action Laboratory, Federal University of Rio Grande do Norte, Natal, Brazil., de Sena MO; Mode of Drug Action Laboratory, Federal University of Rio Grande do Norte, Natal, Brazil., Gavioli EC; Department of Biophysics and Pharmacology, Federal University of Rio Grande do Norte, Natal, Brazil., da Silva Junior ED; Mode of Drug Action Laboratory, Federal University of Rio Grande do Norte, Natal, Brazil.; Department of Biophysics and Pharmacology, Federal University of Rio Grande do Norte, Natal, Brazil.
Jazyk: angličtina
Zdroj: Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2021 Sep; Vol. 129 (3), pp. 183-195. Date of Electronic Publication: 2021 Jul 08.
DOI: 10.1111/bcpt.13633
Abstrakt: The effects of dipyrone and acetylsalicylic acid (ASA) on male fertility are still not fully understood, mainly considering the epididymis as a putative target for their anti-fertility effects. Therefore, this study aimed to investigate the effects of dipyrone and ASA on the contractions of distal cauda epididymis duct, serum testosterone levels and sperm parameters in rats. Firstly, we checked the in vitro effects of dipyrone and ASA (10-1000 μM) on the contractions of distal cauda epididymis duct by pharmacological experiments. We also evaluated the effects of in vivo treatment with dipyrone and ASA 100 mg/kg (p.o.) for 15 days on epididymal duct contractions, serum testosterone levels and sperm parameters. In vitro dipyrone or ASA decreased the epididymal duct contractions induced by phenylephrine or carbachol. We observed that in vivo treatment with both drugs decreased the daily sperm production, serum testosterone levels and sperm count through epididymis without altering the epididymal duct contractions and sperm transit time through epididymis. In conclusion, in vitro dipyrone and ASA were able to diminish the contractions of epididymal duct, whilst in vivo administration decreased the sperm count throughout epididymis as a consequence of a low sperm production caused by reduced testosterone levels.
(© 2021 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society).)
Databáze: MEDLINE
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