Ziziphus jujuba (Rhamnaceae) Alleviates Working Memory Impairment and Restores Neurochemical Alterations in the Prefrontal Cortex of D-Galactose-Treated Rats.

Autor: Kandeda AK; Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon., Nguedia D; Department of Pharmacy, University of the Mountains, P.O. Box 208, Banganté, Cameroon., Ayissi ER; Department of Biological Sciences, Higher Teacher's Training College, University of Yaoundé I, P.O. Box 47, Yaoundé, Cameroon., Kouamouo J; Department of Pharmacy, University of the Mountains, P.O. Box 208, Banganté, Cameroon., Dimo T; Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.
Jazyk: angličtina
Zdroj: Evidence-based complementary and alternative medicine : eCAM [Evid Based Complement Alternat Med] 2021 May 31; Vol. 2021, pp. 6610864. Date of Electronic Publication: 2021 May 31 (Print Publication: 2021).
DOI: 10.1155/2021/6610864
Abstrakt: Alzheimer's disease is a progressive cognitive dysfunction. However, pharmacological treatments are symptomatic and have many side effects, opening the opportunity to alternative medicine. This study investigated the antiamnesic effect of the aqueous extract of Ziziphus jujuba on D-galactose-induced working memory impairment in rats. Impairment of working memory was induced by subcutaneous (s.c.) injection of D-galactose (350 mg/kg/day) to rats for 21 days. These animals were then subjected to object recognition and Y-maze tests. Rats with confirmed memory impairment were treated per os ( p.o. ) with tacrine (10 mg/kg), aspirin (20 mg/kg, p.o. ), extract (41.5, 83, and 166 mg/kg, p.o. ), and distilled water (10 mL/kg, p.o. ) daily for 14 days. At the end of the treatments, alteration in working memory was assessed using the above paradigms. Afterward, these animals were euthanized, and cholinergic, proinflammatory, and neuronal damage markers were analyzed in the prefrontal cortex. Rats administered D-galactose and treated with distilled water had impaired working memory (evidenced by decreased time spent on the novel object and discrimination index) and decreased spontaneous alternation in the Y-maze. D-galactose also decreased the levels of acetylcholinesterase and acetylcholine and increased the level of glial fibrillary acidic protein, ionized calcium-binding adapter molecule 1, tumor necrosis factor-alpha (TNF- α ), interleukin 1 beta (IL-1 β ), interleukin 6 (IL-6), and interferon-gamma (IFN- γ ). Treatment with the extract (166 mg/kg) reversed the time spent on the novel object and the discrimination index. It equally increased the percentage of spontaneous alternation. Neurochemical analysis revealed that the extract markedly alleviated acetylcholinesterase activity and neuroinflammation. These observations were corroborated by the reduction in neuronal loss. Taken together, these results suggest that Ziziphus jujuba aqueous extract possesses an antiamnesic effect. This effect seems to involve cholinergic and anti-inflammatory modulations. This, therefore, claims using this plant in the treatment of dementia in Cameroon subject to further studies and trials.
Competing Interests: The authors declare that there are no conflicts of interest.
(Copyright © 2021 Antoine K. Kandeda et al.)
Databáze: MEDLINE
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