SARS-CoV-2 Among Infants <90 Days of Age Admitted for Serious Bacterial Infection Evaluation.

Autor:	Paret M; Division of Pediatric Infectious Diseases., Lalani K; Department of Pediatrics, Grossman School of Medicine, New York University, New York, New York., Hedari C; Division of Pediatric Infectious Diseases., Jaffer A; Department of Pediatrics, Grossman School of Medicine, New York University, New York, New York., Narayanan N; Division of Pediatric Emergency Medicine, Department of Emergency Medicine, Grossman School of Medicine, New York University, New York, New York., Noor A; Division of Infectious Diseases and Immunology, Department of Medicine, Grossman School of Medicine, New York University, New York, New York., Lighter J; Division of Pediatric Infectious Diseases., Madan RP; Division of Pediatric Infectious Diseases., Shust GF; Division of Pediatric Infectious Diseases., Ratner AJ; Division of Pediatric Infectious Diseases.; Division of Pediatric Infectious Diseases, Department of Pediatrics, Long Island School of Medicine, New York University, Mineola, New York., Raabe VN; Division of Pediatric Infectious Diseases Vanessa.Raabe@nyulangone.org.; Department of Microbiology, Grossman School of Medicine, New York University, New York, New York.
Jazyk:	angličtina
Zdroj:	Pediatrics [Pediatrics] 2021 Oct; Vol. 148 (4). Date of Electronic Publication: 2021 Jun 30.
DOI:	10.1542/peds.2020-044685
Abstrakt:	Objectives: To determine the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in infants hospitalized for a serious bacterial infection (SBI) evaluation and clinically characterize young infants with SARS-CoV-2 infection. Methods: A retrospective chart review was conducted on infants <90 days of age hospitalized for an SBI evaluation. The study was conducted at 4 inpatient facilities in New York City from March 15, 2020, to December 15, 2020. Results: We identified 148 SBI evaluation infants who met inclusion criteria. A total of 22 infants (15%) tested positive for SARS-CoV-2 by nasopharyngeal reverse transcription polymerase chain reaction; 31% of infants admitted during periods of high community SARS-CoV-2 circulation tested positive for SARS-CoV-2, compared with 3% when community SARS-CoV-2 circulation was low ( P < .001). The mean age of infants with SARS-CoV-2 was higher than that of SARS-CoV-2-negative infants (33 [SD: 17] days vs 23 [SD: 23] days, respectively; P = .03), although no age difference was observed when analysis was limited only to febrile infants. An isolated fever was the most common presentation of SARS-CoV-2 ( n = 13; 59%). Admitted infants with SARS-CoV-2 were less likely to have positive urine culture results ( n = 1 [5%] versus n = 25 [20%], respectively; P = .002), positive cerebrospinal culture results ( n = 0 [0%] versus n = 5 [4%], respectively; P = .02), or be admitted to intensive care ( n = 2 [9%] versus n = 47 [37%]; P < .001), compared with infants without SARS-CoV-2. Conclusions: SARS-CoV-2 was common among young infants hospitalized for an SBI evaluation during periods of high but not low community SARS-CoV-2 circulation in New York City, although most infants did not require intensive care admission. Competing Interests: POTENTIAL CONFLICT OF INTEREST: The authors have indicated they have no potential conflicts of interest to disclose. (Copyright © 2021 by the American Academy of Pediatrics.)
Databáze:	MEDLINE
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