Gene-rich UV sex chromosomes harbor conserved regulators of sexual development.

Autor:	Carey SB; Department of Biology, University of Florida, Gainesville, FL, USA., Jenkins J; Genome Sequencing Center, HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA., Lovell JT; Genome Sequencing Center, HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA., Maumus F; Université Paris-Saclay, INRAE, URGI, 78026 Versailles, France., Sreedasyam A; Genome Sequencing Center, HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA., Payton AC; Department of Biology, University of Florida, Gainesville, FL, USA.; RAPiD Genomics, Gainesville, FL, USA., Shu S; U.S. Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Tiley GP; Department of Biology, Duke University, Durham, NC, USA., Fernandez-Pozo N; Plant Cell Biology, University of Marburg, Marburg, Germany., Healey A; Genome Sequencing Center, HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA., Barry K; U.S. Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Chen C; U.S. Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Wang M; U.S. Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Lipzen A; U.S. Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Daum C; U.S. Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Saski CA; Department of Plant and Environmental Sciences, Clemson University, Clemson, SC, USA., McBreen JC; Department of Biology, University of Florida, Gainesville, FL, USA., Conrad RE; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA., Kollar LM; Department of Biology, University of Florida, Gainesville, FL, USA., Olsson S; Department of Forest Ecology and Genetics, INIA-CIFOR, Madrid, Spain., Huttunen S; Department of Biology and Biodiversity Unit, University of Turku, Turku, Finland., Landis JB; L.H. Bailey Hortorium and Section of Plant Biology, School of Integrative Plant Science, Cornell University, Ithaca, NY, USA., Burleigh JG; Department of Biology, University of Florida, Gainesville, FL, USA., Wickett NJ; Negaunee Institute for Plant Conservation Science and Action, Chicago Botanic Garden, Glencoe, IL, USA., Johnson MG; Department of Biological Sciences, Texas Tech University, Lubbock, TX, USA., Rensing SA; Plant Cell Biology, University of Marburg, Marburg, Germany.; Center for Synthetic Microbiology (SYNMIKRO), University of Marburg, Hans-Meerwein-Straße 6, 35032 Marburg, Germany.; BIOSS Centre for Biological Signalling Studies, University of Freiburg, Schänzlestraße 18, 79104 Freiburg im Breisgau, Germany., Grimwood J; Genome Sequencing Center, HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.; U.S. Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Schmutz J; Genome Sequencing Center, HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.; U.S. Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., McDaniel SF; Department of Biology, University of Florida, Gainesville, FL, USA. stuartmcdaniel@ufl.edu.
Jazyk:	angličtina
Zdroj:	Science advances [Sci Adv] 2021 Jun 30; Vol. 7 (27). Date of Electronic Publication: 2021 Jun 30 (Print Publication: 2021).
DOI:	10.1126/sciadv.abh2488
Abstrakt:	Nonrecombining sex chromosomes, like the mammalian Y, often lose genes and accumulate transposable elements, a process termed degeneration. The correlation between suppressed recombination and degeneration is clear in animal XY systems, but the absence of recombination is confounded with other asymmetries between the X and Y. In contrast, UV sex chromosomes, like those found in bryophytes, experience symmetrical population genetic conditions. Here, we generate nearly gapless female and male chromosome-scale reference genomes of the moss Ceratodon purpureus to test for degeneration in the bryophyte UV sex chromosomes. We show that the moss sex chromosomes evolved over 300 million years ago and expanded via two chromosomal fusions. Although the sex chromosomes exhibit weaker purifying selection than autosomes, we find that suppressed recombination alone is insufficient to drive degeneration. Instead, the U and V sex chromosomes harbor thousands of broadly expressed genes, including numerous key regulators of sexual development across land plants. (Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).)
Databáze:	MEDLINE
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