Conventional and Nanotechnology-Based Sensing Methods for SARS Coronavirus (2019-nCoV).

Autor:	Shetti NP; Center for Electrochemical Science and Materials, Department of Chemistry, K.L.E. Institute of Technology, Hubballi 580 027, Karnataka, India., Mishra A; Department of Chemical Engineering, Inha University, Incheon 22212,South Korea., Bukkitgar SD; Center for Electrochemical Science and Materials, Department of Chemistry, K.L.E. Institute of Technology, Hubballi 580 027, Karnataka, India., Basu S; School of Chemistry and Biochemistry, Thapar Institute of Engineering & Technology, Patiala 147004, Punjab, India., Narang J; Department of Biotechnology, School of Chemical and Life Sciences, Jamia Hamdard, Hamdard Nagar, New Delhi 110062, India., Raghava Reddy K; School of Chemical and Biomolecular Engineering, The University of Sydney, Sydney, New South Wales 2006, Australia., Aminabhavi TM; Department of Pharmaceutical Engineering, SET's College of Pharmacy, Dharwad, Karnataka 580 002, India.
Jazyk:	angličtina
Zdroj:	ACS applied bio materials [ACS Appl Bio Mater] 2021 Feb 15; Vol. 4 (2), pp. 1178-1190. Date of Electronic Publication: 2021 Feb 04.
DOI:	10.1021/acsabm.0c01545
Abstrakt:	Ongoing pandemic coronavirus (COVID-19) has affected over 218 countries and infected 88,512,243 and 1,906,853 deaths reported by Jan. 8, 2021. At present, vaccines are being developed in Europe, Russia, USA, and China, although some of these are in phase III of trials, which are waiting to be available for the general public. The only option available now is by vigorous testing, isolation of the infected cases, and maintaining physical and social distances. Numerous methods are now available or being developed for testing the suspected cases, which may act as carriers of the virus. In this review, efforts have been made to discuss the conventional as well as fast, rapid, and efficient testing methods developed for the diagnosis of 2019-nCoV.Testing methods can be based on the sensing of targets, which include RNA, spike proteins and antibodies such as IgG and IgM. Apart from the development of RNA targeted PCR, antibody and VSV pseudovirus neutralization assay along with several other diagnostic techniques have been developed. Additionally, nanotechnology-based sensors are being developed for the diagnosis of the virus, and these are also discussed. Competing Interests: The authors declare no competing financial interest. (© 2021 American Chemical Society.)
Databáze:	MEDLINE
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