Influenza Virus Infects and Depletes Activated Adaptive Immune Responders.

Autor: Bohannon CD; Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA, 30329, USA.; Oak Ridge Institute for Science and Education (ORISE), CDC Fellowship Program, Oak Ridge, TN, 37831, USA., Ende Z; Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA, 30329, USA.; Oak Ridge Institute for Science and Education (ORISE), CDC Fellowship Program, Oak Ridge, TN, 37831, USA., Cao W; Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA, 30329, USA., Mboko WP; Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA, 30329, USA.; Department of Comparative Pathobiology and Purdue Institute for Inflammation, Immunology, and Infectious Disease, Purdue University, West Lafayette, IN, 47907, USA., Ranjan P; Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA, 30329, USA., Kumar A; Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA, 30329, USA., Mishina M; Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA, 30329, USA., Amoah S; Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA, 30329, USA., Gangappa S; Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA, 30329, USA., Mittal SK; Department of Comparative Pathobiology and Purdue Institute for Inflammation, Immunology, and Infectious Disease, Purdue University, West Lafayette, IN, 47907, USA., Lovell JF; Department of Biomedical Engineering, State University of New York at Buffalo, Buffalo, NY, 14260, USA., García-Sastre A; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Pfeifer BA; Department of Chemical and Biological Engineering, School of Engineering and Applied Sciences, State University of New York at Buffalo, Buffalo, NY, 14260, USA., Davidson BA; Department of Anesthesiology, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, 14260, USA.; Department of Pathology and Anatomical Sciences, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, 14260, USA.; Research Service, Veterans Administration, Western New York Healthcare System, Buffalo, NY, 14215, USA., Knight P; Department of Anesthesiology, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, 14260, USA., Sambhara S; Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA, 30329, USA.
Jazyk: angličtina
Zdroj: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2021 Aug; Vol. 8 (16), pp. e2100693. Date of Electronic Publication: 2021 Jun 30.
DOI: 10.1002/advs.202100693
Abstrakt: Influenza infections cause several million cases of severe respiratory illness, hospitalizations, and hundreds of thousands of deaths globally. Secondary infections are a leading cause of influenza's high morbidity and mortality, and significantly factored into the severity of the 1918, 1968, and 2009 pandemics. Furthermore, there is an increased incidence of other respiratory infections even in vaccinated individuals during influenza season. Putative mechanisms responsible for vaccine failures against influenza as well as other respiratory infections during influenza season are investigated. Peripheral blood mononuclear cells (PBMCs) are used from influenza vaccinated individuals to assess antigen-specific responses to influenza, measles, and varicella. The observations made in humans to a mouse model to unravel the mechanism is confirmed and extended. Infection with influenza virus suppresses an ongoing adaptive response to vaccination against influenza as well as other respiratory pathogens, i.e., Adenovirus and Streptococcus pneumoniae by preferentially infecting and killing activated lymphocytes which express elevated levels of sialic acid receptors. These findings propose a new mechanism for the high incidence of secondary respiratory infections due to bacteria and other viruses as well as vaccine failures to influenza and other respiratory pathogens even in immune individuals due to influenza viral infections.
(© 2021 The Authors. Advanced Science published by Wiley-VCH GmbH.)
Databáze: MEDLINE
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