Pain control and functional improvement in patients treated by autologous conditioned serum after failure of platelet rich plasma treatments in knee osteoarthritis.

Autor: Leone R; Transfusion Medicine, San Camillo Forlanini Hospital, Rome, Italy., de Rosa A; Transfusion Medicine, San Camillo Forlanini Hospital, Rome, Italy., Iudicone P; Transfusion Medicine, San Camillo Forlanini Hospital, Rome, Italy., Fioravanti D; Transfusion Medicine, San Camillo Forlanini Hospital, Rome, Italy., Capua G; Sports Medicine Unit, San Camillo Forlanini Hospital, Rome, Italy., Rossetti F; Orthopedics Unit, San Camillo Forlanini Hospital, Rome, Italy., Isgro' MA; Transfusion Medicine, San Camillo Forlanini Hospital, Rome, Italy., Pierelli L; Transfusion Medicine, San Camillo Forlanini Hospital, Rome, Italy.; Department of Experimental Medicine, Sapienza University, Rome, Italy.
Jazyk: angličtina
Zdroj: Transfusion medicine (Oxford, England) [Transfus Med] 2021 Oct; Vol. 31 (5), pp. 357-364. Date of Electronic Publication: 2021 Jun 29.
DOI: 10.1111/tme.12801
Abstrakt: Objective: To assess the efficacy of autologous conditioned serum (ACS) for the treatment of patients with knee osteoarthritis after failure of medical treatments and platelet rich plasma (PRP) injections.
Background: Knee osteoarthritis is the most common form of arthritis. Prior to prosthetic surgery these patients might benefit from medical treatments, physiotherapy, and in case of their ineffectiveness, from autologous blood component injections.
Methodology: We have treated 30 patients with Kellgren-Lawrence I-III knee osteoarthritis with ACS after failure of standard medical treatments/physiotherapy and platelet rich plasma (PRP) injections for a full cycle, within the previous year from enrollment.
Results: ACS administration was performed in all patients with mild side effects and produced prompt (1 month) improvements of VAS and Lequesne scales in 67% of patients and this result persisted at 6 and 12 months. No relationship between the rate of response and Kellgren-Lawrence scale at enrollment was observed whilst responders had a significantly higher amount of interleukin-1 receptor antagonist (IL1-RA) in ACS as compared to nonresponders.
Conclusion: The present study confirms the efficacy of ACS in pain control and functional recovery of patients with knee osteoarthritis resistant to medical and PRP treatment. These results were obtained in a well-defined cohort of resistant patients and seem to be related with IL1-RA content in injected ACS.
(© 2021 British Blood Transfusion Society.)
Databáze: MEDLINE
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