Concept for using magnetic particle imaging for intraoperative margin analysis in breast-conserving surgery.

Autor: Mason EE; Department of Radiology, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, 02129, USA. emason1@mgh.harvard.edu.; Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, 02139, USA. emason1@mgh.harvard.edu., Mattingly E; Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, 02139, USA., Herb K; Department of Radiology, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, 02129, USA.; Department of Physics, ETH Zurich, Zurich, Switzerland., Śliwiak M; Department of Radiology, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, 02129, USA., Franconi S; Department of Radiology, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, 02129, USA., Cooley CZ; Department of Radiology, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, 02129, USA.; Harvard Medical School, Boston, MA, 02115, USA., Slanetz PJ; Department of Radiology, Boston University Medical Center, Boston, MA, 02118, USA., Wald LL; Department of Radiology, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, 02129, USA.; Harvard Medical School, Boston, MA, 02115, USA.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2021 Jun 29; Vol. 11 (1), pp. 13456. Date of Electronic Publication: 2021 Jun 29.
DOI: 10.1038/s41598-021-92644-8
Abstrakt: Breast-conserving surgery (BCS) is a commonly utilized treatment for early stage breast cancers but has relatively high reexcision rates due to post-surgical identification of positive margins. A fast, specific, sensitive, easy-to-use tool for assessing margins intraoperatively could reduce the need for additional surgeries, and while many techniques have been explored, the clinical need is still unmet. We assess the potential of Magnetic Particle Imaging (MPI) for intraoperative margin assessment in BCS, using a passively or actively tumor-targeted iron oxide agent and two hardware devices: a hand-held Magnetic Particle detector for identifying residual tumor in the breast, and a small-bore MPI scanner for quickly imaging the tumor distribution in the excised specimen. Here, we present both hardware systems and demonstrate proof-of-concept detection and imaging of clinically relevant phantoms.
Databáze: MEDLINE
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