| Autor: |
Zhu RZ; Department of Biochemistry, Wonkwang University School of Medicine, Iksan 54538, Korea., Li BS; Department of Biochemistry, Wonkwang University School of Medicine, Iksan 54538, Korea., Gao SS; Department of Biochemistry, Wonkwang University School of Medicine, Iksan 54538, Korea., Seo JH; Department of Biochemistry, Wonkwang University School of Medicine, Iksan 54538, Korea., Choi BM; Department of Biochemistry, Wonkwang University School of Medicine, Iksan 54538, Korea. |
| Jazyk: |
angličtina |
| Zdroj: |
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology [Korean J Physiol Pharmacol] 2021 Jul 01; Vol. 25 (4), pp. 297-305. |
| DOI: |
10.4196/kjpp.2021.25.4.297 |
| Abstrakt: |
Luteolin, a sort of flavonoid, has been reported to be involved in neuroprotective function via suppression of neuroinflammation. In this study, we investigated the protective effect of luteolin against oxidative stress-induced cellular senescence and its molecular mechanism using hydrogen peroxide (H 2 O 2 )-induced cellular senescence model in House Ear Institute-Organ of Corti 1 cells (HEI-OC1). Our results showed that luteolin attenuated senescent phenotypes including alterations of morphology, cell proliferation, senescence-associated β -galactosidase expression, DNA damage, as well as related molecules expression such as p53 and p21 in the oxidant challenged model. Interestingly, we found that luteolin induces expression of sirtuin 1 in dose- and time-dependent manners and it has protective role against H 2 O 2 -induced cellular senescence by upregulation of sirtuin 1 (SIRT1). In contrast, the inhibitory effect of luteolin on cellular senescence under oxidative stress was abolished by silencing of SIRT1. This study indicates that luteolin effectively protects against oxidative stress-induced cellular senescence through p53 and SIRT1. These results suggest that luteolin possesses therapeutic potentials against age-related hearing loss that are induced by oxidative stress. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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