Detection of Crimean-Congo hemorrhagic fever virus in blood-fed Hyalomma ticks collected from Mauritanian livestock.

Autor: Schulz A; Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Südufer 10, 17493, Greifswald-Insel Riems, Germany., Barry Y; Office National de Recherches et de Développement de l'Elevage (ONARDEL), Nouakchott, Mauritania., Stoek F; Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Südufer 10, 17493, Greifswald-Insel Riems, Germany., Pickin MJ; Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Südufer 10, 17493, Greifswald-Insel Riems, Germany., Ba A; Office National de Recherches et de Développement de l'Elevage (ONARDEL), Nouakchott, Mauritania., Chitimia-Dobler L; Bundeswehr Institute of Microbiology, Neuherbergstrasse 11, 80937, Munich, Germany., Haki ML; Office National de Recherches et de Développement de l'Elevage (ONARDEL), Nouakchott, Mauritania., Doumbia BA; Ministère du Développement Rural, Nouakchott, Mauritania., Eisenbarth A; Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Südufer 10, 17493, Greifswald-Insel Riems, Germany., Diambar A; Office National de Recherches et de Développement de l'Elevage (ONARDEL), Nouakchott, Mauritania., Bah MY; Ministère du Développement Rural, Nouakchott, Mauritania., Eiden M; Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Südufer 10, 17493, Greifswald-Insel Riems, Germany., Groschup MH; Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Südufer 10, 17493, Greifswald-Insel Riems, Germany. martin.groschup@fli.de.
Jazyk: angličtina
Zdroj: Parasites & vectors [Parasit Vectors] 2021 Jun 29; Vol. 14 (1), pp. 342. Date of Electronic Publication: 2021 Jun 29.
DOI: 10.1186/s13071-021-04819-x
Abstrakt: Background: Crimean-Congo hemorrhagic fever virus (CCHFV) belongs to the genus Orthonairovirus (Nairovididae) and is a (re)emerging tick-borne pathogen. It is endemic in most parts of Africa, Asia and southern Europe, and can cause severe hemorrhagic symptoms in humans, with high fatality rates (5-30%).
Methods: Hyalomma ticks were collected from four different livestock herds (cattle and camels) in Mauritania in 2018. The tick species were determined morphologically and confirmed molecularly by using the cytochrome oxidase 1 gene marker. For the detection of CCHFV, ticks were tested individually by one-step multiplex real-time reverse-transcriptase quantitative polymerase chain reaction. The small segment of all positive samples was sequenced to determine the CCHFV genotype.
Results: In total, 39 of the 1523 ticks (2.56%) collected from 63 cattles and 28 camels tested positive for CCHFV. Three Hyalomma species were identified. Hyalomma rufipes had the largest proportion of positivity (5.67%; 16/282), followed by Hyalomma dromedarii (1.89%; 23/1214). No Hyalomma impeltatum tested positive (0%; 0/21). Positive ticks were found in only six out of 91 host animals. Viral sequence analysis revealed the presence of two different CCHFV lineages (Africa I and Africa III).
Conclusions: In this study, 2.56% of Hyalomma ticks collected from camels and cattle in Mauritania tested positive for CCHFV. However, the true prevalence of CCHFV in unfed ticks may be lower, as a considerable number of ticks may have been passively infected during blood-feeding by co-feeding ticks or due to viremia of the host. The results indicate the need to track the actual area of circulation of this virus.
Databáze: MEDLINE
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