Schwann cell precursors generate sympathoadrenal system during zebrafish development.

Autor: Kamenev D; Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden., Sunadome K; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., Shirokov M; National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, Vladivostok, Russia., Chagin AS; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.; Institute for Regenerative Medicine, Sechenov University, Moscow, Russia., Singh A; Max-Planck-Institut für Entwicklungsbiologie, Tübingen, Germany., Irion U; Max-Planck-Institut für Entwicklungsbiologie, Tübingen, Germany., Adameyko I; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.; Center for Brain Research, Medical University Vienna, Vienna, Austria., Fried K; Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden., Dyachuk V; National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, Vladivostok, Russia.
Jazyk: angličtina
Zdroj: Journal of neuroscience research [J Neurosci Res] 2021 Oct; Vol. 99 (10), pp. 2540-2557. Date of Electronic Publication: 2021 Jun 28.
DOI: 10.1002/jnr.24909
Abstrakt: The autonomic portion of the peripheral nervous system orchestrates tissue homeostasis through direct innervation of internal organs, and via release of adrenalin and noradrenalin into the blood flow. The developmental mechanisms behind the formation of autonomic neurons and chromaffin cells are not fully understood. Using genetic tracing, we discovered that a significant proportion of sympathetic neurons in zebrafish originates from Schwann cell precursors (SCPs) during a defined period of embryonic development. Moreover, SCPs give rise to the main portion of the chromaffin cells, as well as to a significant proportion of enteric and other autonomic neurons associated with internal organs. The conversion of SCPs into neuronal and chromaffin cells is ErbB receptor dependent, as the pharmacological inhibition of the ErbB pathway effectively perturbed this transition. Finally, using genetic ablations, we revealed that SCPs producing neurons and chromaffin cells migrate along spinal motor axons to reach appropriate target locations. This study reveals the evolutionary conservation of SCP-to-neuron and SCP-to-chromaffin cell transitions over significant growth periods in fish and highlights relevant cellular-genetic mechanisms. Based on this, we anticipate that multipotent SCPs might be present in postnatal vertebrate tissues, retaining the capacity to regenerate autonomic neurons and chromaffin cells.
(© 2021 Wiley Periodicals LLC.)
Databáze: MEDLINE
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