Prognostic accuracy of a peripheral blood transcriptome signature in chronic hypersensitivity pneumonitis.

Autor:	Fernández Pérez ER; Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health Department of Medicine, Denver, Colorado, USA fernandezevans@njhealth.org., Harmacek LD; Center for Genes, Environment and Health, National Jewish Health, Denver, Colorado, USA., O'Connor BP; Center for Genes, Environment and Health, National Jewish Health, Denver, Colorado, USA., Danhorn T; Biostatistics and Bioinformatics Shared Resource, University of Colorado Cancer Center, Auroa, Colorado, USA., Vestal B; Center for Genes, Environment and Health, National Jewish Health, Denver, Colorado, USA., Maier LA; Division of Occupational Health and Environmental Health Sciences, National Jewish Health Department of Medicine, Denver, Colorado, USA., Koelsch TL; Thoracic Radiology, National Jewish Health, Denver, Colorado, USA., Leach SM; Center for Genes, Environment and Health, National Jewish Health, Denver, Colorado, USA.
Jazyk:	angličtina
Zdroj:	Thorax [Thorax] 2022 Jan; Vol. 77 (1), pp. 86-90. Date of Electronic Publication: 2021 Jun 28.
DOI:	10.1136/thoraxjnl-2020-214790
Abstrakt:	The prognostic value of peripheral blood mononuclear cell (PBMC) expression profiles, when used in patients with chronic hypersensitivity pneumonitis (CHP), as an adjunct to traditional clinical assessment is unknown. RNA-seq analysis on PBMC from 37 patients with CHP at initial presentation determined that (1) 74 differentially expressed transcripts at a 10% false discovery rate distinguished those with (n=10) and without (n=27) disease progression, defined as absolute FVC and/or diffusing capacity of the lungs for carbon monoxide (DLCO) decline of ≥10% and increased fibrosis on chest CT images within 24 months, and (2) classification models based on gene expression and clinical factors strongly outperform models based solely on clinical factors (baseline FVC%, DLCO% and chest CT fibrosis). Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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