Ethnicity-specific alterations of plasma and hepatic lipidomic profiles are related to high NAFLD rate and severity in Hispanic Americans, a pilot study.

Autor: Mazi TA; Department of Nutrition, University of California Davis, 3135 Meyer Hall, One Shields Avenue, Davis, CA, 95616, USA; Department of Community Health Sciences-Clinical Nutrition, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, Riyadh, 11433, Saudi Arabia. Electronic address: tmazi.20@gmail.com., Borkowski K; West Coast Metabolomic Center, Genome Center, University of California-Davis, Davis, CA, 95616, USA., Newman JW; West Coast Metabolomic Center, Genome Center, University of California-Davis, Davis, CA, 95616, USA; United States Department of Agriculture-Agriculture Research Service-Western Human Nutrition Research Center, Davis, CA, 95616, USA; Department of Nutrition, University of California-Davis, Davis, CA, 95616, USA., Fiehn O; West Coast Metabolomic Center, Genome Center, University of California-Davis, Davis, CA, 95616, USA., Bowlus CL; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of California Davis, 4150 V Street, Suite 3500 Sacramento, CA, 95817, USA., Sarkar S; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of California Davis, 4150 V Street, Suite 3500 Sacramento, CA, 95817, USA., Matsukuma K; Department of Pathology and Laboratory Medicine, University of California-Davis, Sacramento, CA, 95817, USA., Ali MR; Department of Surgery, University of California, Davis, 2221 Stockton Boulevard, Cypress Building, Sacramento, CA, 95817, USA., Kieffer DA; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of California Davis, 4150 V Street, Suite 3500 Sacramento, CA, 95817, USA., Wan YY; Department of Pathology and Laboratory Medicine, University of California-Davis, Sacramento, CA, 95817, USA., Stanhope KL; Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA., Havel PJ; Department of Nutrition, University of California-Davis, Davis, CA, 95616, USA; Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA., Medici V; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of California Davis, 4150 V Street, Suite 3500 Sacramento, CA, 95817, USA. Electronic address: vmedici@ucdavis.edu.
Jazyk: angličtina
Zdroj: Free radical biology & medicine [Free Radic Biol Med] 2021 Aug 20; Vol. 172, pp. 490-502. Date of Electronic Publication: 2021 Jun 25.
DOI: 10.1016/j.freeradbiomed.2021.06.024
Abstrakt: Nonalcoholic fatty liver disease (NAFLD) is a progressive condition that includes steatosis (NAFL) and nonalcoholic steatohepatitis (NASH). In the U.S., Hispanics (HIS) are afflicted with NAFLD at a higher rate and severity compared to other ethnicities. To date, the mechanisms underlying this disparity have not been elucidated. In this pilot study, we compared untargeted plasma metabolomic profiles for primary metabolism, complex lipids, choline and related compounds between a group of HIS (n = 7) and White Caucasian (CAU, n = 8) subjects with obesity and biopsy-characterized NAFL to ethnicity-matched lean healthy controls (n = 14 HIS and 8 CAU). We also compared liver and plasma metabolomic profiles in a group of HIS and CAU subjects with obesity and NASH of comparable NAFLD Activity Scores, to BMI-matched NASH-free subjects in both ethnicities. Results highlight signs of metabolic dysregulation observed in HIS, independent of obesity, including higher plasma triglycerides, acylcarnitines, and free fatty acids. With NASH progression, there were ethnicity-related differences in the hepatic profile, including higher free fatty acids and lysophospholipids seen in HIS, suggesting lipotoxicity is involved in the progression of NASH. We also observed greater hepatic triglyceride content, higher plasma triglyceride concentrations and lower hepatic phospholipids with signs of impaired hepatic mitochondrial β-oxidation. These findings provide preliminary evidence indicating ethnicity-related variations that could potentially modulate the risk for progression of NALD to NASH.
(Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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