Serum albumin levels and inflammation.

Autor: Sheinenzon A; Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel., Shehadeh M; Department of Biochemistry, Galilee Medical Center, Nahariya, Israel., Michelis R; Department of Hematology, Galilee Medical Center, Nahariya, Israel., Shaoul E; Department of Hematology, Galilee Medical Center, Nahariya, Israel., Ronen O; Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel; Department of Otolaryngology, Head and Neck Surgery, Galilee Medical Center, Nahariya, Israel. Electronic address: ohadr@gmc.gov.il.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2021 Aug 01; Vol. 184, pp. 857-862. Date of Electronic Publication: 2021 Jun 25.
DOI: 10.1016/j.ijbiomac.2021.06.140
Abstrakt: Albumin is the most abundant protein in the plasma and has a regulatory role in the distribution of body fluids, acid-base physiology, and binding of essential components in the bloodstream. C-reactive protein (CRP) is produced by hepatocytes and is commonly used to assess inflammation. It was previously noted that acute-phase concentrations of proteins, such as CRP, tend to rise in inflammatory conditions, while albumin concentrations tend to decline. This study assessed the correlation between albumin levels and various inflammatory indices (CRP, WBC, PLT) of patients hospitalized at the Galilee Medical Center over a period of 3 months. The study population consisted of 4434 patients, ages 18-107 years (mean: 52 years), of whom 60% were female. A negative correlation between albumin and CRP levels (r = -0.311) was identified, as well as between albumin and white blood cells levels (r = -0.157). Positive correlations were found between albumin and platelets levels (r = 0.084), as well as between albumin and hemoglobin levels (r = 0.513). When considering the three largest departments, the strongest negative correlation between albumin and CRP was identified in the Internal Medicine departments. A linear regression analysis discovered a fairly minor effect of CRP on albumin levels, which only became apparent when CRP levels were extremely high (500 mg/L). The mechanisms underlying this negative correlation still need to be explored.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: