Negligible Nux Vomica: Homeopathic Nux Vomica remedies don't contain strychnine?

Autor: Downs J; Department of Emergency Medicine, Division of Medical Toxicology Virginia Commonwealth University Health System, USA. Electronic address: downsjw2000@gmail.com., Wolf CE; Division of Medical Toxicology Virginia Commonwealth University Health System, Richmond, VA, USA. Electronic address: carl.wolf@vcuhealth.org., Williams G; Department of Pathology, Virginia Commonwealth University Health System, Richmond, VA, USA. Electronic address: grace.r.williams@vcuhealth.org., Cumpston KL; Department of Emergency Medicine, Division of Medical Toxicology Virginia Commonwealth University Health System, USA. Electronic address: kirk.cumpston@vcuhealth.org., Kershner E; Department of Emergency Medicine, Division of Medical Toxicology Virginia Commonwealth University Health System, USA. Electronic address: Emily.Kershner@vcuhealth.org., Wills BK; Department of Emergency Medicine, Division of Medical Toxicology Virginia Commonwealth University Health System, USA. Electronic address: brandon.wills@vcuhealth.org.
Jazyk: angličtina
Zdroj: Toxicon : official journal of the International Society on Toxinology [Toxicon] 2021 Sep; Vol. 200, pp. 1-2. Date of Electronic Publication: 2021 Jun 25.
DOI: 10.1016/j.toxicon.2021.06.014
Abstrakt: Introduction: The St. Ignatius bean of the Strychnos ignatii tree and Nux Vomica homeopathic products presumably could contain the toxic alkaloids strychnine and brucine. This study aimed to determine the amount of these toxic alkaloids in some commercially available Nux Vomica products and the St. Ignatius bean and to determine if overdose of these products could result in clinically significant toxicity.
Methods: Using ultra-performance liquid chromatography-tandem mass spectrometry, various formulations of Nux Vomica products and St. Ignatius beans were analyzed for strychnine, and brucine with detection limits set at 0.1 ng/g.
Results: None of the analyzed Nux Vomica products contained any detectable strychnine or brucine, while the expected strychnine dose from a St. Ignatius bean would be < 0.001 mg.
Conclusions: Overall, our study reveals that the amount of strychnine in homeopathic Nux Vomica products or St. Ignatius beans are not likely to result in clinically significant strychnine toxicity.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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