Nuclear factor-kappa B and its role in inflammatory lung disease.

Autor: Alharbi KS; Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Al-Jouf, Saudi Arabia., Fuloria NK; Faculty of Pharmacy, AIMST University, Kedah, 08100, Malaysia., Fuloria S; Faculty of Pharmacy, AIMST University, Kedah, 08100, Malaysia., Rahman SB; Bengal School of Technology, Churchura, Hooghly, West Bengal, India., Al-Malki WH; Department of Pharmacology, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia., Javed Shaikh MA; School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, 302017, Mahal Road, Jaipur, India., Thangavelu L; Department of Pharmacology, Saveetha Dental College, Saveetha University, Chennai, India., Singh SK; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411, India., Rama Raju Allam VS; Department of Medical Biochemistry and Microbiology, Biomedical Centre (BMC), Uppsala University, Uppsala, Sweden., Jha NK; Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Plot No.32-34, Knowledge Park III, Greater Noida, 201310, Uttar Pradesh, India., Chellappan DK; Department of Life Sciences, School of Pharmacy, International Medical University, Kuala Lumpur, 57000, Malaysia., Dua K; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, NSW, 2007, Australia. Electronic address: kamalpharmacist@gmail.com., Gupta G; School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, 302017, Mahal Road, Jaipur, India. Electronic address: gauravpharma25@gmail.com.
Jazyk: angličtina
Zdroj: Chemico-biological interactions [Chem Biol Interact] 2021 Aug 25; Vol. 345, pp. 109568. Date of Electronic Publication: 2021 Jun 25.
DOI: 10.1016/j.cbi.2021.109568
Abstrakt: Nuclear factor-kappa B, involved in inflammation, host immune response, cell adhesion, growth signals, cell proliferation, cell differentiation, and apoptosis defense, is a dimeric transcription factor. Inflammation is a key component of many common respiratory disorders, including asthma, chronic obstructive pulmonary disease (COPD), bronchiectasis, and acute respiratory distress syndrome. Many basic transcription factors are found in NF-κB signaling, which is a member of the Rel protein family. Five members of this family c-REL, NF-κB2 (p100/p52), RelA (p65), NF-κB1 (p105/p50), RelB, and RelA (p65) produce 5 transcriptionally active molecules. Proinflammatory cytokines, T lymphocyte, and B lymphocyte cell mitogens, lipopolysaccharides, bacteria, viral proteins, viruses, double-stranded RNA, oxidative stress, physical exertion, various chemotherapeutics are the stimulus responsible for NF-κB activation. NF-κB act as a principal component for several common respiratory illnesses, such as asthma, lung cancer, pulmonary fibrosis, COPD as well as infectious diseases like pneumonia, tuberculosis, COVID-19. Inflammatory lung disease, especially COVID-19, can make NF-κB a key target for drug production.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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