Atypical hematological manifestation of celiac disease: A case report of aplastic anemia in a 2-year-old child and review of the literature.

Autor: von Graffenried T; Pediatric Gastroenterology Unit Department of Pediatrics University of Lausanne Centre Hospitalier Universitaire Vaudois Lausanne Switzerland., Rizzi M; Hemato-Oncology Unit Department of Pediatrics University of Lausanne Switzerland., Russo M; Department of Pediatrics Centre Hospitalier du Valais Romand Sion Switzerland., Nydegger A; Pediatric Gastroenterology Unit Department of Pediatrics University of Lausanne Centre Hospitalier Universitaire Vaudois Lausanne Switzerland., Kayemba-Kay's S; Department of Pediatrics Centre Hospitalier du Valais Romand Sion Switzerland.; Department of Pediatrics Centre Hospitalier des Pays de Morlaix France.
Jazyk: angličtina
Zdroj: Pediatric investigation [Pediatr Investig] 2021 Jun 18; Vol. 5 (2), pp. 159-162. Date of Electronic Publication: 2021 Jun 18 (Print Publication: 2021).
DOI: 10.1002/ped4.12267
Abstrakt: Introduction: Celiac disease typically presents with symptoms of malabsorption, but extraintestinal manifestations are increasingly reported. Aplastic anemia as the mode of celiac disease presentation is extremely rare in children.
Case Presentation: We report a 2-year-old boy who presented with loose stools, loss of appetite, and bicytopenia with severe aregenerative normocytic anemia. Investigations, including bone marrow aspirate and biopsy, revealed aplastic anemia. Screening for malabsorption showed increased plasma concentrations of anti-transglutaminase and anti-gliadin antibodies. A duodenal biopsy confirmed the histologic features of celiac disease. The child received a packed red cell transfusion and was started on a gluten-free diet, with a very good prognosis and normalization of both his blood and histological parameters. To the best of our knowledge, our report is the sixth pediatric case in the literature.
Conclusion: Screening for celiac disease should be performed in children with unexplained hematological abnormalities such as aplastic anemia with or without gastrointestinal symptoms.
Competing Interests: None.
(© 2021 Chinese Medical Association. Pediatric Investigation published by John Wiley & Sons Australia, Ltd on behalf of Futang Research Center of Pediatric Development.)
Databáze: MEDLINE
Externí odkaz: