Spaceflight decelerates the epigenetic clock orchestrated with a global alteration in DNA methylome and transcriptome in the mouse retina.

Autor:	Chen Z; Center for Genomics, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USA., Stanbouly S; Center for Genomics, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USA., Nishiyama NC; Division of Radiation Research, Department of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA 92354, USA., Chen X; Center for Genomics, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USA., Delp MD; Department of Nutrition and Integrative Physiology, Florida State University, Tallahassee, FL 32306, USA., Qiu H; Center for Molecular and Translational Medicine, Institute of Biomedical Science, Georgia State University, Atlanta, GA 30303, USA., Mao XW; Division of Radiation Research, Department of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA 92354, USA., Wang C; Center for Genomics, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USA.
Jazyk:	angličtina
Zdroj:	Precision clinical medicine [Precis Clin Med] 2021 May 17; Vol. 4 (2), pp. 93-108. Date of Electronic Publication: 2021 May 17 (Print Publication: 2021).
DOI:	10.1093/pcmedi/pbab012
Abstrakt:	Astronauts exhibit an assortment of clinical abnormalities in their eyes during long-duration spaceflight. The purpose of this study was to determine whether spaceflight induces epigenomic and transcriptomic reprogramming in the retina or alters the epigenetic clock. The mice were flown for 37 days in animal enclosure modules on the International Space Station; ground-based control animals were maintained under similar housing conditions. Mouse retinas were isolated and both DNA methylome and transcriptome were determined by deep sequencing. We found that a large number of genes were differentially methylated with spaceflight, whereas there were fewer differentially expressed genes at the transcriptome level. Several biological pathways involved in retinal diseases such as macular degeneration were significantly altered. Our results indicated that spaceflight decelerated the retinal epigenetic clock. This study demonstrates that spaceflight impacts the retina at the epigenomic and transcriptomic levels, and such changes could be involved in the etiology of eye-related disorders among astronauts. (© The Author(s) 2021. Published by Oxford University Press on behalf of the West China School of Medicine & West China Hospital of Sichuan University.)
Databáze:	MEDLINE
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