The New Kid on the Block: The Mechanisms of Action of Hyperleptinemia in Coronary Artery Disease and Atherosclerosis.
| Autor: | Hernandez V; Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Kaur K; Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., ElSharief MW; Pediatrics and Child Health, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Al Hajaj SW; Surgery, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Ebrahim AM; Surgery, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Razack M; Emergency Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.; Internal Medicine, Wuhan University, Wuhan, CHN.; Internal Medicine, Al Ain Hospital, Al Ain, ARE., Dragas D; Research, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2021 Jun 20; Vol. 13 (6), pp. e15766. Date of Electronic Publication: 2021 Jun 20. |
| DOI: | 10.7759/cureus.15766 |
| Abstrakt: | Leptin is an adipocytokine that consists of 167 amino acids. It functions as a regulator of hunger and energy expenditure. Leptin loses its ability to carry out its physiological function at high serum levels, and many studies have associated this loss of function with the development of coronary artery disease (CAD). This literature review aims to outline the steps by which leptin leads to CAD and atherosclerosis. Two independent researchers extracted animal and human studies from PubMed and Google Scholar databases. We applied PubMed search builder options: pathology, pathophysiology, metabolism, and physiology to focus the search results. This study concluded that the mechanism by which leptin might lead to CAD via pressor and depressor effects on vascular tone, enhancing atherosclerotic plaques, and through numerous single nucleotide polymorphisms, the most common being that of the leptin receptor gene rs113701. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2021, Hernandez et al.) |
| Databáze: | MEDLINE |
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