Renal replacement therapy in cancer patients with acute kidney injury (Review).

Autor: Lupuşoru M; Department of Physiology 1, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania., Lupuşoru G; Department of Nephrology, 'Fundeni' Clinical Institute, 022328 Bucharest, Romania.; Department of Uronephrology, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania., Ailincăi I; Department of Nephrology, 'Fundeni' Clinical Institute, 022328 Bucharest, Romania., Frățilă G; Department of Nephrology, 'Fundeni' Clinical Institute, 022328 Bucharest, Romania., Andronesi A; Department of Nephrology, 'Fundeni' Clinical Institute, 022328 Bucharest, Romania.; Department of Uronephrology, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania., Micu E; Department of Nephrology, 'Fundeni' Clinical Institute, 022328 Bucharest, Romania.; Department of Uronephrology, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania., Banu M; Department of Morphology, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania., Costea R; Department of General Surgery, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania., Ismail G; Department of Physiology 1, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.; Department of Nephrology, 'Fundeni' Clinical Institute, 022328 Bucharest, Romania.
Jazyk: angličtina
Zdroj: Experimental and therapeutic medicine [Exp Ther Med] 2021 Aug; Vol. 22 (2), pp. 864. Date of Electronic Publication: 2021 Jun 11.
DOI: 10.3892/etm.2021.10296
Abstrakt: Cancer patients are at high risk for developing acute kidney injury (AKI), which is associated with increased morbidity and mortality in these patients. Despite the progress made in understanding the pathogenic mechanisms and etiology of AKI in these patients, the main prevention consists of avoiding medication and nephrotoxic agents such as non-steroidal anti-inflammatory drugs, contrast agents used in medical imaging and modulation of chemotherapy regimens; when prophylactic measures are overcome and renal impairment becomes unresponsive to treatment, renal replacement therapy (RRT) is required. There are several methods of RRT that can be utilized for patients with malignancies and acute renal impairment; the choice of treatment being based on the patient characteristics. The aim of this article is to review the literature data regarding the epidemiology and management of AKI in cancer patients, the extracorporeal techniques used, choice of the appropriate therapy and the optimal time of initiation, and also the dose-prognosis relationship.
Competing Interests: The authors declare that they have no competing interests.
(Copyright: © Lupuşoru et al.)
Databáze: MEDLINE
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