| Autor: |
Romo SA; Periodontics Postgraduate Program, School of Dentistry, Autonomous University of San Luis Potosí, Mexico., Martinez-Morales F; Department of Pharmacology, School of Medicine, Autonomous University of San Luis Potosí, Mexico., Aragon-Martinez OH; Department of Pharmacology, School of Medicine, Autonomous University of San Luis Potosí, Mexico. |
| Jazyk: |
angličtina |
| Zdroj: |
Dental and medical problems [Dent Med Probl] 2021 Apr-Jun; Vol. 58 (2), pp. 253-266. |
| DOI: |
10.17219/dmp/133512 |
| Abstrakt: |
The adjunctive use of fluoroquinolone (FQ) agents in patients with periodontitis produces contradictory results. There has been no meta-analysis performed based on the evaluations of FQ use that would enable making appropriate clinical decisions. Our study aimed to evaluate, via a systematic review and metaanalysis conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) guidelines, the clinical benefits, antimicrobial effects and safety profiles of the FQ agents administered to periodontitis patients under a conventional treatment regime. Relevant databases were searched for studies published up to May 2020, with the quality and risk of bias evaluations performed on the selected studies, and meta-analyses, funnel plots and heterogeneity tests carried out based on the obtained data. Any finding of p-value less than 0.05 was considered statistically significant. Quality and the risk of bias ranged from high to low. With acceptable heterogeneity and no reporting bias, the meta-analyses showed that local or systemic FQ use produced the following results: a reduced probing depth change (ΔPD) (p < 0.00001 at ≤3 months); reduced bleeding on probing (BOP) (p < 0.00001 at 3-6 months); reduced subgingival detection of Aggregatibacter actinomycetemcomitans for up to 12 months (p-values from <0.00001 to 0.001); and an insignificant number of adverse events (p ≥ 0.05) in patients subjected to a conventional therapy as compared to those subjected to an antibiotic-free therapy. Our study found evidence to show that FQ administration provides clinical benefits and ensures antibacterial effects in periodontitis patients subjected to a conventional therapy regime. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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