| Autor: |
Kirst HA; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Ose EE, Toth JE, Willard KE, Debono M, Felty-Duckworth AM, Pekarek RS |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of antibiotics [J Antibiot (Tokyo)] 1988 Jul; Vol. 41 (7), pp. 938-48. |
| DOI: |
10.7164/antibiotics.41.938 |
| Abstrakt: |
Three series of semi-synthetic derivatives of tylosin-related macrolides were evaluated for utility in veterinary medicine. 23-Modified derivatives of 5-O-mycaminosyltylonolide (OMT) possessed potent activity in vitro against species of Pasteurella and Mycoplasma. An experimental infection in chicks caused by Pasteurella multocida was utilized to evaluate efficacy; several of these derivatives of OMT effectively treated the infection when given subcutaneously, but none were effective after oral administration in drinking water. Macrolides retaining the 4'-O-mycarosyl moiety (tylosin, DMT) had relatively poor activity against Pasteurella in vitro. Certain 20-modified derivatives of desmycosin demonstrated good oral bioavailability in chicks and a lead compound with oral efficacy in the Pasteurella infection model was discovered. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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