| Autor: |
Pagliosa CM; Post-graduate Program in Nutrition, Health Sciences Center, Federal University of Santa Catarina, Florianópolis, Brazil. edson.silva@ufsc.br dasilvael@hotmail.com., Vieira FGK, Dias BV, Brognoli Franco VK, Ramos HP, da Silva EL |
| Jazyk: |
angličtina |
| Zdroj: |
Food & function [Food Funct] 2021 Aug 21; Vol. 12 (16), pp. 7321-7328. Date of Electronic Publication: 2021 Jun 26. |
| DOI: |
10.1039/d1fo00482d |
| Abstrakt: |
This study proposed to investigate the effect of Ilex paraguariensis infusion on the absorption of non-heme iron in hereditary hemochromatosis (HH) patients with the HFE genotype. A two-way randomized, controlled, crossover trial was conducted on patients, aged 29-69 years, undergoing maintenance therapy. Fourteen HFE-HH patients ingested a meal containing 11.4 mg iron and 200 mL either of water (control) or of Ilex paraguariensis leaf infusion. The beverages were offered in random order, at intervals separated by a washout period of 7 days. Active surveillance showed no adverse effects. Blood samples were drawn shortly before and 1, 2, 3, and 4 h after the meal for serum iron measurement. A significant reduction in the postprandial serum iron was observed for HH patients after intake of the Ilex paraguariensis infusion (area under the curve (AUC) expressed as mean ± SEM: 173.3 ± 44.7 μmol h -1 L -1 ) compared to water (1449.4 ± 241.5 μmol h -1 L -1 ) (p < 0.001). In summary, intake of Ilex paraguariensis leaf infusion significantly inhibited the absorption of iron in patients with HH and, therefore, should be considered as a potential adjuvant for iron overload control. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
