Influence of gender on cytokine induced depression and treatment: Gender aspects of IFN-α-induced depression.

Autor: Sarkar S; Department of Clinical Psychology and Psychotherapy, Universität Hamburg, Hamburg, Germany., Kemper J; Department of Psychiatry, Psychotherapy, Psychosomatics and Addiction Medicine, Evang. Kliniken Essen-Mitte, Essen, Germany., Sarkar R; Department of Psychiatry, Psychotherapy and Psychosomatics, Sana-Regio Elmshorn, Germany., Brants L; Department of Psychiatry and Psychotherapy, Charité Campus Mitte, Charité-Universitätsmedizin Berlin, Germany., Friebe A; Praxis für Psychiatrie und Psychotherapie, Trödelmarkt, Nürnberg, Germany., Spengler U; Department of Internal Medicine I, Universitätsklinikum Bonn, Germany., Schläpfer T; Division of Interventional Biological Psychiatry, Department of Psychiatry and Psychotherapy, University Hospital Freiburg, Germany., Reimer J; Zentrum für psychosoziale Medizin, Klinikum Bremen-Ost, Bremen, Germany., Buggisch P; Institute for Interdisciplinary Medicine, Asklepios-Clinic, St. Georg, Hamburg, Germany., Ockenga J; Department of Gastroenterology, Medizinische Klinik II, Klinikum Bremen-Mitte, Germany., Link R; Medizinisches Versorgungszentrum, Gastroenterology and Hepatology, Offenburg, Germany., Rentrop M; Klinische Sozialpsychiatrie, kbo-Inn-Salzach-Klinikum Wasserburg am Inn, Gabersee, Germany., Weidenbach H; Department of Gastroenterology and Internal Medicine, Klinikum Mittelbaden, Baden Baden, Germany., Fromm G; Department of Psychiatry and Psychotherapy, Universitätsklinikum Giessen, Germany., Lieb K; Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Germany., Baumert TF; Institute of Viral and Liver Disease, Laboratory of Excellence HepSYS, University of Strasbourg,France., Discher T; Department of Internal Medicine II, Universitätsklinikum Giessen, Germany., Zeuzem S; Department of Gastroenterology and Hepatology, Medizinische Klinik I, Goethe Universität, Frankfurt/Main, Germany., Berg T; Division of Hepatology; Department of Oncology, Gastroenterology and Infectious Disease, Universitätsklinikum Leipzig, Germany., Schaefer M; Department of Clinical Psychology and Psychotherapy, Universität Hamburg, Hamburg, Germany; Department of Psychiatry and Psychotherapy, Charité Campus Mitte, Charité-Universitätsmedizin Berlin, Germany. Electronic address: m.schaefer@kem-med.com.
Jazyk: angličtina
Zdroj: Journal of affective disorders [J Affect Disord] 2021 Sep 01; Vol. 292, pp. 766-772. Date of Electronic Publication: 2021 Jun 23.
DOI: 10.1016/j.jad.2021.05.087
Abstrakt: Background: Cytokine treatment with Interferon-alpha (IFN-α) represents a clinical model of immune associated depression, but it remains unclear if it is of the same entity as major depressive disorder (MDD). The study focuses on possible gender differences in IFN-α induced depression and effects of a pre-emptive antidepressant treatment.
Methods: Data from 181 patients with chronic hepatitis C infection (cHC) without history of mental illnesses undergoing treatment with IFN-α 2a and ribavirin were re-analyzed for gender effects. Patients with a pre-emptive antidepressant therapy with Escitalopram (n = 90, verum group) to prevent IFN-induced depression were compared to patients who received placebo (n = 91). Depressive symptoms before and during HCV-treatment were assessed using the Montgomery-Asberg Depression Rating Scale (MADRS), Beck's Depression Inventory (BDI) and the Hamilton Anxiety Rating Scale.
Results: We found significant differences regarding the incidence and severity of depressive symptoms between men and women for patients without antidepressant pre-treatment (placebo group). Significantly more women without pre-emptive antidepressant therapy suffered from clinically relevant depression (MADRS values ≥ 13, p = 0.041) and self-rated depressive symptoms (BDI ≥ 17, p = 0.024). Antidepressant pre-treatment showed comparable effects regarding the reduction of incidence and severity of depression in both women and men.
Conclusions: Compared to MDD, IFN-alpha-induced depression in patients with cHC is also characterized by gender differences with an increased risk for women but no gender difference regarding the effects of an antidepressant pre-treatment is found. Our data strengthens the hypothesis that Interferon-induced depression serves as a clinical model for immune related depressive disorders.
(Copyright © 2021. Published by Elsevier B.V.)
Databáze: MEDLINE
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