Construction of congested Csp 3 -Csp 3 bonds by a formal Ni-catalyzed alkylboration.
| Autor: | Simlandy AK; Department of Chemistry, Indiana University 800E. Kirkwood Ave Bloomington IN 47401 USA brownmkb@indiana.edu., Sardini SR; Department of Chemistry, Indiana University 800E. Kirkwood Ave Bloomington IN 47401 USA brownmkb@indiana.edu., Brown MK; Department of Chemistry, Indiana University 800E. Kirkwood Ave Bloomington IN 47401 USA brownmkb@indiana.edu. |
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| Jazyk: | angličtina |
| Zdroj: | Chemical science [Chem Sci] 2021 Mar 09; Vol. 12 (15), pp. 5517-5521. Date of Electronic Publication: 2021 Mar 09. |
| DOI: | 10.1039/d1sc00900a |
| Abstrakt: | Through the combination of a Ni-catalyzed alkene alkenylboration followed by hydrogenation, the synthesis of congested Csp 3 -Csp 3 -bonds can be achieved. Conditions have been identified that allow for the use of both alkenyl-bromides and -triflates. In addition, the hydrogenation creates another opportunity for stereocontrol, thus allowing access to multiple stereoisomers of the product. Finally, the method is demonstrated in the streamlined synthesis of a biologically relevant molecule. Competing Interests: There are no conflicts to declare. (This journal is © The Royal Society of Chemistry.) |
| Databáze: | MEDLINE |
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