The Effect of Radiation on Meningioma Volume Change.

Autor: Hall JT; Department of Neurosurgery, Virginia Commonwealth University, Richmond, Virginia, USA., Opalak CF; Department of Neurosurgery, Virginia Commonwealth University, Richmond, Virginia, USA., Carr MT; Department of Neurosurgery, Virginia Commonwealth University, Richmond, Virginia, USA., Harris TJ; Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia, USA., Broaddus WC; Department of Neurosurgery, Virginia Commonwealth University, Richmond, Virginia, USA; Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia, USA. Electronic address: William.broaddus@vcuhealth.org.
Jazyk: angličtina
Zdroj: World neurosurgery [World Neurosurg] 2021 Sep; Vol. 153, pp. e141-e146. Date of Electronic Publication: 2021 Jun 21.
DOI: 10.1016/j.wneu.2021.06.080
Abstrakt: Background: Radiation therapy is a common treatment for meningiomas. Volume changes of meningiomas in response to radiation are not well characterized. This study seeks to quantify the volume change of meningiomas following radiation.
Methods: Data were collected from a retrospective single-institution database of cases from 2005-2015. Tumors were measured using T1-weighted post-contrast magnetic resonance imaging. Volumes were calculated using the ABC/2 ellipsoidal approximation.
Results: A total of 63 patients fit the inclusion criteria; 37 patients (59%) received radiation following resection, 19 (30%) received radiation alone, 4 (6%) received radiation following a biopsy, and 3 (5%) had unknown surgical status. A total of 39 patients (62%) had skull base meningiomas; 43 tumors were World Health Organization (WHO) grade I, and 12 tumors were WHO grade II. Thirteen patients received radiosurgery, 43 received radiotherapy, and 7 received an unknown number of treatments. Eight patients did not attain local control and were excluded from volume analyses. WHO grade I meningiomas saw an average of 33% ± 19% decrease in tumor volume; WHO grade II tumor volumes decreased by an average 30% ± 23%. Radiosurgery saw an average volume decrease of 34% ± 13%, while radiotherapy resulted in volume decrease of 31% ± 21%. For those who achieved local control, there was an average decrease in tumor size of 30% ± 19%, 30% ± 22%, and 41% ± 19% over 0.5-1.5, 2.5-3.5, and >5 years, respectively.
Conclusions: Meningiomas treated with radiation exhibit nonlinear decrease in size over time. The greatest decrease in tumor volume occurs within the first year and begins to plateau 5 years post-radiation treatment.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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