A Systematic Review of Dietary Supplements and Alternative Therapies for Weight Loss.

Autor: Batsis JA; Division of Geriatric Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Department of Nutrition, The Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Apolzan JW; Pennington Biomedical Research Center, Louisiana State University Sysytem, Baton Rouge, Louisiana, USA., Bagley PJ; Department of Biomedical Libraries, Dartmouth College, Hanover, New Hampshire, USA., Blunt HB; Department of Biomedical Libraries, Dartmouth College, Hanover, New Hampshire, USA., Divan V; Stormont Vail Health, Topeka, Kansas, USA., Gill S; University of California, Davis, School of Medicine, Sacramento, California, USA., Golden A; NP Obesity Treatment Clinic, Flagstaff, Arizona, USA., Gundumraj S; Cornell University, Ithaca, New York, USA., Heymsfield SB; Pennington Biomedical Research Center, Louisiana State University Sysytem, Baton Rouge, Louisiana, USA., Kahan S; National Center for Weight and Wellness, George Washington University Milken Institute School of Public Health, Washington, DC, USA., Kopatsis K; George Washington University, Washington, DC, USA., Port A; Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA., Parks EP; Division of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; The Healthy Weight Program, Perelman Medical Center, University of Pennsylvania, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Reilly CA; The Robert Larner, M.D. College of Medicine at The University of Vermont, Burlington, Vermont, USA., Rubino D; Washington Center for Weight Management and Research, Arlington, Virginia, USA., Saunders KH; Division of Endocrinology, Diabetes, and Metabolism, Weill Cornell Medicine, Comprehensive Weight Control Center, New York, New York, USA., Shean R; Department of Biomedical Libraries, Dartmouth College, Hanover, New Hampshire, USA., Tabaza L; Albert Einstein Medical Center, Philadelphia, Pennsylvania, USA., Stanley A; Pennington Biomedical Research Center, Louisiana State University Sysytem, Baton Rouge, Louisiana, USA., Tchang BG; Division of Endocrinology, Diabetes, and Metabolism, Weill Cornell Medicine, Comprehensive Weight Control Center, New York, New York, USA., Gundumraj S; A.T, Still University School of Osteopathic Medicine in Arizona, Mesa, Arizona, USA., Kidambi S; Division of Endocrinology and Molecular Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Jazyk: angličtina
Zdroj: Obesity (Silver Spring, Md.) [Obesity (Silver Spring)] 2021 Jul; Vol. 29 (7), pp. 1102-1113.
DOI: 10.1002/oby.23110
Abstrakt: Objective: Dietary supplements and alternative therapies are commercialized as a panacea for obesity/weight gain as a result of the minimal regulatory requirements in demonstrating efficacy. These products may indirectly undermine the value of guideline-driven obesity treatments. Included in this study is a systematic review of the literature of purported dietary supplements and alternative therapies for weight loss.
Methods: A systematic review was conducted to evaluate the efficacy of dietary supplements and alternative therapies for weight loss in participants aged ≥18 years. Searches of Medline (PubMed), Cochrane Library, Web of Science, CINAHL, and Embase (Ovid) were conducted. Risk of bias and results were summarized qualitatively.
Results: Of the 20,504 citations retrieved in the database search, 1,743 full-text articles were reviewed, 315 of which were randomized controlled trials evaluating the efficacy of 14 purported dietary supplements, therapies, or a combination thereof. Risk of bias and sufficiency of data varied widely. Few studies (n = 52 [16.5%]) were classified as low risk and sufficient to support efficacy. Of these, only 16 (31%) noted significant pre/post intergroup differences in weight (range: 0.3-4.93 kg).
Conclusions: Dietary supplements and alternative therapies for weight loss have a limited high-quality evidence base of efficacy. Practitioners and patients should be aware of the scientific evidence of claims before recommending use.
(© 2021 The Obesity Society.)
Databáze: MEDLINE
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