Role of innate immunity and myeloid cells in susceptibility to allergic disease.

Autor: Noel JC; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York., Berin MC; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Jazyk: angličtina
Zdroj: Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2021 Sep; Vol. 1499 (1), pp. 42-53. Date of Electronic Publication: 2021 Jun 22.
DOI: 10.1111/nyas.14654
Abstrakt: Allergic diseases, including asthma, food allergy, eczema, and allergic rhinitis, are common diseases increasing in prevalence. Allergy, a failure of immune tolerance to innocuous environmental allergens, is characterized by allergen-specific immune responses, including IgE antibodies and T helper and T follicular helper cells producing type 2 cytokines. Despite the central role of adaptive immunity in pathophysiology of allergy, there is a growing body of evidence indicating an important role for the innate immune system in allergic disease. In this review, we focus on epithelial-mononuclear phagocyte communication in the control of allergy and tolerance. We discuss studies on early life environmental exposures and allergy susceptibility, and the evidence for innate training of mononuclear phagocytes as the mechanistic link between exposure and health or disease.
(© 2021 New York Academy of Sciences.)
Databáze: MEDLINE
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