Associations of Alcohol Consumption with Cardiovascular Disease-Related Proteomic Biomarkers: The Framingham Heart Study.

Autor:	Sun X; Department of Biostatistics, School of Public Health, Boston University, Boston, MA, USA., Ho JE; Division of Cardiology, Department of Medicine and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Gao H; Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom., Evangelou E; Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom.; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece., Yao C; Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA, USA.; Population Sciences Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA., Huan T; Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA, USA.; Population Sciences Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA., Hwang SJ; Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA, USA.; Population Sciences Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA., Courchesne P; Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA, USA.; Population Sciences Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA., Larson MG; Department of Biostatistics, School of Public Health, Boston University, Boston, MA, USA.; Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA, USA., Levy D; Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA, USA.; Population Sciences Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA., Ma J; Nutrition Epidemiology and Data Science, Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA., Liu C; Department of Biostatistics, School of Public Health, Boston University, Boston, MA, USA.; Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA, USA.
Jazyk:	angličtina
Zdroj:	The Journal of nutrition [J Nutr] 2021 Sep 04; Vol. 151 (9), pp. 2574-2582.
DOI:	10.1093/jn/nxab186
Abstrakt:	Background: Alcohol consumption and cardiovascular disease (CVD) have a complex relation. Objectives: We examined the associations between alcohol consumption, fasting plasma proteins, and CVD risk. Methods: We performed cross-sectional association analyses of alcohol consumption with 71 CVD-related plasma proteins, and also performed prospective association analyses of alcohol consumption and protein concentrations with 3 CVD risk factors (obesity, hypertension, and diabetes) in 6745 Framingham Heart Study (FHS) participants (mean age 49 y; 53% women). Results: A unit increase in log10 transformed alcohol consumption (g/d) was associated with an increased risk of hypertension (HR = 1.14; 95% CI: 1.04, 1.26; P = 0.007), and decreased risks of obesity (HR = 0.80; 95% CI: 0.71, 0.91; P = 4.6 × 10-4) and diabetes (HR: 0.68; 95% CI: 0.58, 0.80; P = 5.1 × 10-6) in a median of 13-y (interquartile = 7, 14) of follow-up. We identified 43 alcohol-associated proteins in a discovery sample (n = 4348, false discovery rate <0.05) and 20 of them were significant (P <0.05/43) in an independent validation sample (n = 2397). Eighteen of the 20 proteins were inversely associated with alcohol consumption. Four of the 20 proteins demonstrated 3-way associations, as expected, with alcohol consumption and CVD risk factors. For example, a greater concentration of APOA1 was associated with higher alcohol consumption (P = 1.2 × 10-65), and it was also associated with a lower risk of diabetes (P = 8.5 × 10-6). However, several others showed unexpected 3-way associations. Conclusions: We identified 20 alcohol-associated proteins in 6745 FHS samples. These alcohol-associated proteins demonstrated complex relations with the 3 CVD risk factors. Future studies with integration of more proteomic markers and larger sample size are warranted to unravel the complex relation between alcohol consumption and CVD risk. (© The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu