Gut microbiota mediate the FGF21 adaptive stress response to chronic dietary protein-restriction in mice.

Autor: Martin A; F. Widjaja Foundation Inflammatory Bowel & Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Ecklu-Mensah G; Department of Pediatrics and Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA, USA., Ha CWY; F. Widjaja Foundation Inflammatory Bowel & Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Hendrick G; F. Widjaja Foundation Inflammatory Bowel & Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Layman DK; Department of Food Science and Human Nutrition, University of Illinois, Urbana, IL, USA., Gilbert J; Department of Pediatrics and Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA, USA., Devkota S; F. Widjaja Foundation Inflammatory Bowel & Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Suzanne.Devkota@cshs.org.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2021 Jun 22; Vol. 12 (1), pp. 3838. Date of Electronic Publication: 2021 Jun 22.
DOI: 10.1038/s41467-021-24074-z
Abstrakt: Chronic dietary protein-restriction can create essential amino acid deficiencies and induce metabolic adaptation through the hepatic FGF21 pathway which serves to maintain host fitness during prolonged states of nutritional imbalance. Similarly, the gut microbiome undergoes metabolic adaptations when dietary nutrients are added or withdrawn. Here we confirm previous reports that dietary protein-restriction triggers the hepatic FGF21 adaptive metabolic pathway and further demonstrate that this response is mediated by the gut microbiome and can be tuned through dietary supplementation of fibers that alter the gut microbiome. In the absence of a gut microbiome, we discover that FGF21 is de-sensitized to the effect of protein-restriction. These data suggest that host-intrinsic adaptive pathways to chronic dietary protein-restriction, such as the hepatic FGF21 pathway, may in-fact be responding first to adaptive metabolic changes in the gut microbiome.
Databáze: MEDLINE
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