Impact of Brazil Nut ( Bertholletia excelsa , H.B.K.) Supplementation on Body Composition, Blood Pressure, and the Vascular Reactivity of Wistar Rats When Submitted to a Hypersodium Diet.

Autor:	Saldanha Melo H; Cardiovascular Sciences Postgraduate Program, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil., Monnerat JAS; Cardiovascular Sciences Postgraduate Program, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil., Costa NDS; Cardiovascular Sciences Postgraduate Program, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil., Bento Bernardes T; Molecular Endocrinology Laboratory, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Niterói, Rio de Janeiro, Brazil., Magliano DC; Cardiovascular Sciences Postgraduate Program, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil.; Laboratory of Morphological and Metabolic Analyses, Department of Morphology, Biomedical Institute, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil., Pereira AD; Laboratory of Experimental Nutrition, Department of Nutrition and Dietetics, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil., Almeida PP; Cardiovascular Sciences Postgraduate Program, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil., Lima GF; Laboratory of Experimental Pharmacology, Department of Physiology and Pharmacology, Biomedical Institute, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil., Ferreira de Brito FC; Cardiovascular Sciences Postgraduate Program, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil.; Laboratory of Experimental Pharmacology, Department of Physiology and Pharmacology, Biomedical Institute, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil., Stockler Pinto MB; Cardiovascular Sciences Postgraduate Program, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil.; Department of Nutrition and Dietetics, College of Nutrition, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil.; Nutrition Sciences Postgraduate Program, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil., Kindlovits R; Cardiovascular Sciences Postgraduate Program, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil., Nogueira AB; Laboratory of Exercise Sciences, Department of Physiology and Pharmacology, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil., Sepúlveda-Fragoso V; Cardiovascular Sciences Postgraduate Program, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil., Nóbrega ACLD; Cardiovascular Sciences Postgraduate Program, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil.; Laboratory of Exercise Sciences, Department of Physiology and Pharmacology, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil., Motta NAVD; Cardiovascular Sciences Postgraduate Program, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil.; Laboratory of Experimental Pharmacology, Department of Physiology and Pharmacology, Biomedical Institute, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil., Medeiros RF; Cardiovascular Sciences Postgraduate Program, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil.; Department of Nutrition and Dietetics, College of Nutrition, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil.; Nutrition Sciences Postgraduate Program, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil.; Laboratory of Exercise Sciences, Department of Physiology and Pharmacology, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil.
Jazyk:	angličtina
Zdroj:	Journal of the American Nutrition Association [J Am Nutr Assoc] 2022 Aug; Vol. 41 (6), pp. 559-568. Date of Electronic Publication: 2021 Jun 22.
DOI:	10.1080/07315724.2021.1925995
Abstrakt:	Introdution: Endothelium integrity is a key that maintains vascular homeostasis but it can suffer irreversible damage by blood pressure changes, reflecting an imbalance in the maintenance of vascular homeostasis. Objective: The aim of this study was to investigate the impact of Brazil nut (Bertholletia excelsa, H.B.K.) (BN) supplementation (10% in chow, wt/wt) on the vascular reactivity of Wistar rats during chronic exposure to a sodium overload (1% in water). Methods: First, male Wistar rats were allocated into two groups: Control Group (CG) and the Hypersodic Group (HG) for 4 weeks. Afterward, the CG was divided into the Brazil Nut Group (BNG) and the HG Group into the Hypersodic Brazil Nut Group (HBNG) for a further 8 weeks, totaling 4 groups. Blood pressure was measured during the protocol. At the end of the protocol, the vascular reactivity procedure was performed. Glucose, lipid profile, lipid peroxidation, and platelet aggregation were analyzed in the serum. Body composition was determined by the carcass technique. Results: The groups that were supplemented with the BN chow presented less body mass gain and body fat mass, together with lower serum glucose levels. The HG Group presented an increase in blood pressure and a higher platelet aggregation, while the BN supplementation was able to blunt this effect. The HG Group also showed an increase in contractile response that was phenylephrine-induced and a decrease in maximum relaxation that was acetylcholine-induced when compared to the other groups. Conclusion: The BN supplementation was able to prevent an impaired vascular function in the early stages of arterial hypertension, while also improving body composition, serum glucose, and platelet aggregation.
Databáze:	MEDLINE
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