Academic Performance in Adolescents Born to Mothers With Gestational Diabetes-A National Danish Cohort Study.

Autor:	Heldarskard GF; The Fertility Clinic, Rigshospitalet, Copenhagen, Denmark.; Department of Gynecology and Obstetrics, Nordsjællands Hospital, Hillerød, Denmark.; University of Copenhagen, Copenhagen, Denmark., Spangmose AL; The Fertility Clinic, Rigshospitalet, Copenhagen, Denmark.; University of Copenhagen, Copenhagen, Denmark., Henningsen AA; The Fertility Clinic, Rigshospitalet, Copenhagen, Denmark.; University of Copenhagen, Copenhagen, Denmark., Wiingreen R; University of Copenhagen, Copenhagen, Denmark.; Department of Neonatology, Rigshospitalet, Copenhagen, Denmark.; Department of Pediatrics, Nordsjællands Hospital, Hillerød, Denmark., Mortensen EL; University of Copenhagen, Copenhagen, Denmark.; Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Gundersen TW; Department of Gynecology and Obstetrics, Nordsjællands Hospital, Hillerød, Denmark.; University of Copenhagen, Copenhagen, Denmark., Jensen RB; University of Copenhagen, Copenhagen, Denmark.; Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark., Knorr S; Steno Diabetes Center Aarhus, Aarhus University Hospital, Denmark., Damm P; University of Copenhagen, Copenhagen, Denmark.; Center for Pregnant Women with Diabetes, Department of Obstetrics, Rigshospitalet and Department of Clinical Medicine, Copenhagen, Denmark., Forman JL; Section of Biostatistics, Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Pinborg A; The Fertility Clinic, Rigshospitalet, Copenhagen, Denmark.; University of Copenhagen, Copenhagen, Denmark., Clausen TD; Department of Gynecology and Obstetrics, Nordsjællands Hospital, Hillerød, Denmark.; University of Copenhagen, Copenhagen, Denmark.
Jazyk:	angličtina
Zdroj:	The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2021 Oct 21; Vol. 106 (11), pp. e4554-e4564.
DOI:	10.1210/clinem/dgab451
Abstrakt:	Context: The prevalence of gestational diabetes mellitus (GDM) is increasing, and intrauterine hyperglycemia is suspected to affect offspring cognitive function. Objective: We assessed academic performance by grade point average (GPA) in children aged 15 to 16 years at compulsory school graduation, comparing offspring exposed to GDM (O-GDM) with offspring from the background population (O-BP). Methods: This register-based, cohort study comprised all singletons born in Denmark between 1994 and 2001 (O-GDM: n = 4286; O-BP: n = 501 045). Standardized and internationally comparable GPAs were compared in univariate and multivariable linear models. Main outcome measures included the adjusted mean difference in GPA. We also analyzed the probability of having a high GPA, a GPA below passing, and no GPA registered. Results: O-GDM had a GPA of 6.29 (SD 2.52), whereas O-BP had a GPA of 6.78 (SD 2.50). The adjusted mean difference was -0.36 (95% CI, -0.44 to -0.29), corresponding to a Cohen's D of 0.14. O-GDM had a lower probability of obtaining a high GPA (adjusted odds ratio [aOR] 0.68; 95% CI, 0.59 to 0.79), while their risk of obtaining a GPA below passing was similar to O-BP (aOR 1.20; 95% CI, 0.96 to 1.50). O-GDM had a higher risk of not having a GPA registered (aOR 1.38; 95% CI, 1.24 to 1.53). Conclusion: Academic performance in O-GDM was marginally lower than in O-BP. However, this difference is unlikely to be of clinical importance. (© The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society.)
Databáze:	MEDLINE
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