Genomes reveal selective sweeps in kiang and donkey for high-altitude adaptation.

Autor: Zeng L; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China.; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204, China., Liu HQ; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China.; Department of Genetics, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA., Tu XL; Annoroad Gene Tech. (Beijing) Co., Ltd., Beijing 100176, China., Ji CM; Hainan Key Laboratory for Biosafety Monitoring and Molecular Breeding in Off-Season Reproduction Regions, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan 571101, China.; Biomarker Technologies Corporation, Beijing 101300, China., Gou X; College of Animal Science and Technology, Yunnan Agricultural University, Kunming, Yunnan 650201, China., Esmailizadeh A; Department of Animal Science, Faculty of Agriculture, Shahid Bahonar University of Kerman, Kerman, PB 76169-133, Iran., Wang S; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China., Wang MS; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China., Wang MC; Biomarker Technologies Corporation, Beijing 101300, China., Li XL; Biomarker Technologies Corporation, Beijing 101300, China., Charati H; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China.; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204, China., Adeola AC; State Key Laboratory of Genetic Resources and Evolution, Yunnan Laboratory of Molecular Biology of Domestic Animals, Germplasm Bank of Wild Species, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China.; Sino-Africa Joint Research Center, Chinese Academy of Sciences, Kunming, Yunnan 650223, China., Moshood Adedokun RA; Department of Veterinary Medicine, University of Ibadan, Ibadan 200284, Nigeria., Oladipo O; Federal College of Animal Health and Production Technology, Moor-Plantation, Ibadan, Nigeria., Olaogun SC; Department of Veterinary Medicine, University of Ibadan, Ibadan 200284, Nigeria., Sanke OJ; Taraba State Ministry of Agriculture and Natural Resources, Jalingo 660221, Nigeria., Godwin F M; Division of Veterinary Office, Serti 663101, Nigeria., Cecily Ommeh S; Institute For Biotechnology Research Jomo Kenyatta University of Agriculture and Technology, Nairobi 62000-00200, Kenya.; Department of Zoology, National Museums of Kenya, Nairobi 40658-00100, Kenya., Agwanda B; Department of Zoology, National Museums of Kenya, Nairobi 40658-00100, Kenya., Kasiiti Lichoti J; State Department of Livestock, Ministry of Agriculture, Livestock, Fisheries and Irrigation, Nairobi, Kenya., Han JL; CAAS-ILRI Joint Laboratory on Livestock and Forage Genetic Resources, Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China., Zheng HK; Biomarker Technologies Corporation, Beijing 101300, China., Wang CF; Equus Laboratory, Dairy Cattle Research Center, Shandong Academy of Agricultural Sciences, Ji'nan, Shandong 250131, China.; Liaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding, Liaocheng University, Liaocheng, Shandong 252059, China. E-mail:wangcf1967@163.com., Zhang YP; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China.; Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, Yunnan 650223, China. E-mail:zhangyp@mail.kiz.ac.cn., Frantz LAF; School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London E1 4NS, UK. E-mail:laurent.frantz@qmul.ac.uk., Wu DD; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China.; Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, Yunnan 650223, China.; Institute of Three-River-Source National Park, Chinese Academy of Sciences, Qinghai 810008, China. E-mail:wudongdong@mail.kiz.ac.c.
Jazyk: angličtina
Zdroj: Zoological research [Zool Res] 2021 Jul 18; Vol. 42 (4), pp. 450-460.
DOI: 10.24272/j.issn.2095-8137.2021.095
Abstrakt: Over the last several hundred years, donkeys have adapted to high-altitude conditions on the Tibetan Plateau. Interestingly, the kiang, a closely related equid species, also inhabits this region. Previous reports have demonstrated the importance of specific genes and adaptive introgression in divergent lineages for adaptation to hypoxic conditions on the Tibetan Plateau. Here, we assessed whether donkeys and kiangs adapted to the Tibetan Plateau via the same or different biological pathways and whether adaptive introgression has occurred. We assembled a de novo genome from a kiang individual and analyzed the genomes of five kiangs and 93 donkeys (including 24 from the Tibetan Plateau). Our analyses suggested the existence of a strong hard selective sweep at the EPAS1 locus in kiangs. In Tibetan donkeys, however, another gene, i.e., EGLN1 , was likely involved in their adaptation to high altitude. In addition, admixture analysis found no evidence for interspecific gene flow between kiangs and Tibetan donkeys. Our findings indicate that despite the short evolutionary time scale since the arrival of donkeys on the Tibetan Plateau, as well as the existence of a closely related species already adapted to hypoxia, Tibetan donkeys did not acquire adaptation via admixture but instead evolved adaptations via a different biological pathway.
Databáze: MEDLINE
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