Thymol in fattening rabbit diet, its bioavailability and effects on intestinal morphology, microbiota from caecal content and immunity.

Autor: Placha I; Centre of Biosciences-Slovak Academy of Sciences-Institute of Animal Physiology, Kosice, Slovak Republic., Bacova K; Centre of Biosciences-Slovak Academy of Sciences-Institute of Animal Physiology, Kosice, Slovak Republic., Zitterl-Eglseer K; Institute of Animal Nutrition and Functional Plant Compounds, University of Veterinary Medicine Vienna, Vienna, Austria., Laukova A; Centre of Biosciences-Slovak Academy of Sciences-Institute of Animal Physiology, Kosice, Slovak Republic., Chrastinova L; National Agricultural and Food Centre, Nitra-Luzianky, Slovak Republic., Madarova M; Centre of Biosciences-Slovak Academy of Sciences-Institute of Animal Physiology, Kosice, Slovak Republic., Zitnan R; National Agricultural and Food Centre, Nitra-Luzianky, Slovak Republic., Strkolcova G; Department of Epizootiology, Parasitology and Protection of One Health, University of Veterinary Medicine and Pharmacy, Kosice, Slovak Republic.
Jazyk: angličtina
Zdroj: Journal of animal physiology and animal nutrition [J Anim Physiol Anim Nutr (Berl)] 2022 Mar; Vol. 106 (2), pp. 368-377. Date of Electronic Publication: 2021 Jun 22.
DOI: 10.1111/jpn.13595
Abstrakt: To our knowledge, no study has been carried out to evaluate the effects of thymol sustained administration on gut health and immune response in terms of its bioavailability in the rabbit organism. A total of 48 rabbits were randomly divided at 35 days of age into two dietary treatment groups (C/control or T/thymol at 0.025% addition). Thymol was added for 21 days and then withdrawn for 7 days. Thymol content in faeces (p < 0.001) and caecal content (p < 0.05) was significantly higher than in plasma during the thymol addition and withdrawal (2442 ± 451.4, 881.9 ± 231.3 ng/g DM and 46.2 ± 28.4 ng/ml, respectively; 149.5 ± 40.54, 45.76 ± 12.44 ng/g DM and 2.73 ± 0.45 ng/ml, respectively). Increasing of villi height to crypt depth ratio in small intestinal wall (p < 0.01), phagocytic activity in blood (p < 0.0001) and lactic acid bacteria in caecal appendix (p < 0.01) and faeces (p < 0.05) was still presented after withdrawn of thymol. The thymol at this concentration demonstrated its biological properties and was able to positively affect gut health and immune response of rabbits.
(© 2021 Wiley-VCH GmbH.)
Databáze: MEDLINE
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