Oxcarbazepine-Induced Hyponatremia: A Case Report and Comprehensive Literature Review.
| Autor: | Ejikeme C; Internal Medicine, Rutgers New Jersey Medical School/Trinitas Regional Medical Center, Elizabeth, USA., Elkattawy S; Internal Medicine, Rutgers New Jersey Medical School/Trinitas Regional Medical Center, Elizabeth, USA., Kayode-Ajala F; Internal Medicine, Trinitas Regional Medical Center, Elizabeth, USA., Abuaita S; Internal Medicine, St George's University, True Blue, GRD., Khazai M; Nephrology, Trinitas Regional Medical Center, Elizabeth, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2021 May 18; Vol. 13 (5), pp. e15085. Date of Electronic Publication: 2021 May 18. |
| DOI: | 10.7759/cureus.15085 |
| Abstrakt: | Oxcarbazepine is a well-known and effective anti-convulsant used for patients with underlying seizure disorder. It is a structural analog of carbamazepine; however, it follows a different metabolic pathway in which it is converted to a different active metabolite. Side effects associated with this medication are vast; however, in this report, we will hone in on the renal adverse effects, e.g., syndrome of inappropriate anti-diuretic hormone secretion (SiADH). SiADH is a condition in which the body is making too much anti-diuretic hormone, which, in turn, results in "too much" water absorption, causing hyponatremia with neurologic sequelae. Our patient is a 31-year-old gentleman with a history of depression, anxiety, bipolar disorder, and previous suicide attempts who presented to the emergency department following oxcarbazepine overdose and was subsequently found to be hyponatremic secondary to having SiADH. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2021, Ejikeme et al.) |
| Databáze: | MEDLINE |
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