Characteristics and outcomes of patients hospitalized for COVID-19 in France: The Critical COVID-19 France (CCF) study.

Autor: Bonnet G; Université de Paris, PARCC, inserm, 75015 Paris, France; Hôpital Européen Georges-Pompidou, Université de Paris, 75015 Paris, France., Weizman O; Université de Paris, PARCC, inserm, 75015 Paris, France; Centre Hospitalier Régional Universitaire de Nancy, 54511 Vandoeuvre-Les-Nancy, France., Trimaille A; Nouvel hopital Civil, Centre Hospitalier régional universitaire de Strasbourg, 67000 Strasbourg, France., Pommier T; Lariboisiere hospital, AP-HP, university of Paris, 75010 Paris, France; Centre Hospitalier Universitaire de Dijon, 21000 Dijon, France., Cellier J; Hôpital Européen Georges-Pompidou, Université de Paris, 75015 Paris, France., Geneste L; Centre Hospitalier universitaire d'Amiens-Picardie, 80000 Amiens, France., Panagides V; Centre Hospitalier Universitaire de Marseille, 13005 Marseille, France., Marsou W; GCS-Groupement des Hôpitaux de l'Institut Catholique de Lille, Faculté de Médecine et de Maïeutique, Université Catholique de Lille, Lille, France., Deney A; Centre Hospitalier universitaire de Toulouse, 31400 Toulouse, France., Attou S; Centre Hospitalier universitaire de Caen-Normandie, 14000 Caen, France., Delmotte T; Centre Hospitalier universitaire de Reims, 51100 Reims, France., Ribeyrolles S; Institut mutualiste Montsouris, 75014 Paris, France., Chemaly P; Institut Cardiovasculaire Paris Sud, 91300 Massy, France., Karsenty C; Centre Hospitalier universitaire de Toulouse, 31400 Toulouse, France., Giordano G; Centre Hospitalier Régional Universitaire de Nancy, 54511 Vandoeuvre-Les-Nancy, France., Gautier A; Institut Cardiovasculaire Paris Sud, 91300 Massy, France., Chaumont C; Rouen University Hospital, FHU REMOD-VHF, 76000 Rouen, France., Guilleminot P; Centre Hospitalier Universitaire de Dijon, 21000 Dijon, France., Sagnard A; Centre Hospitalier Universitaire de Dijon, 21000 Dijon, France., Pastiero J; Centre Hospitalier Universitaire de Dijon, 21000 Dijon, France., Ezzouhairi N; Centre Hospitalier universitaire de Bordeaux, 33076 Bordeaux, France., Perin B; Centre Hospitalier Régional Universitaire de Nancy, 54511 Vandoeuvre-Les-Nancy, France., Zakine C; Clinique Saint-Gatien, 37540 Saint-Cyr-sur-Loire, France., Levasseur T; Centre Hospitalier intercommunal Fréjus-Saint-Raphaël, 83600 Fréjus, France., Ma I; Hôpital Européen Georges-Pompidou, Université de Paris, 75015 Paris, France., Chavignier D; Centre Hospitalier régional de Orléans, 45100 Orléans, France., Noirclerc N; Centre Hospitalier Annecy Genevois, 74370 Epagny Metz-Tessy, France., Darmon A; Hôpital Bichat-Claude-Bernard, AP-HP, université de Paris, 75018 Paris, France., Mevelec M; Centre Hospitalier régional de Orléans, 45100 Orléans, France., Duceau B; Université de Paris, PARCC, inserm, 75015 Paris, France; Centre Hospitalier Régional Universitaire de Nancy, 54511 Vandoeuvre-Les-Nancy, France., Sutter W; Université de Paris, PARCC, inserm, 75015 Paris, France; Centre Hospitalier Régional Universitaire de Nancy, 54511 Vandoeuvre-Les-Nancy, France., Mika D; Université Paris-Saclay, Inserm, UMR-S 1180, 92296 Chatenay-Malabry, France., Fauvel C; Rouen University Hospital, FHU REMOD-VHF, 76000 Rouen, France., Pezel T; Lariboisiere hospital, AP-HP, university of Paris, 75010 Paris, France., Waldmann V; Université de Paris, PARCC, inserm, 75015 Paris, France; Hôpital Européen Georges-Pompidou, Université de Paris, 75015 Paris, France., Cohen A; Hôpital Saint-Antoine, Saint-Antoine and Tenon hospitals, AP-HP, Inserm UMRS-ICAN 1166 Sorbonne-Université, French Society of Cardiology 2020-2022, 184, rue du Faubourg Saint-Antoine, 75012 Paris, France. Electronic address: ariel.cohen@aphp.fr.
Jazyk: angličtina
Zdroj: Archives of cardiovascular diseases [Arch Cardiovasc Dis] 2021 May; Vol. 114 (5), pp. 352-363. Date of Electronic Publication: 2021 Mar 02.
DOI: 10.1016/j.acvd.2021.01.003
Abstrakt: Background: The coronavirus disease 2019 (COVID-19) pandemic has led to a public health crisis. Only limited data are available on the characteristics and outcomes of patients hospitalized for COVID-19 in France.
Aims: To investigate the characteristics, cardiovascular complications and outcomes of patients hospitalized for COVID-19 in France.
Methods: The Critical COVID-19 France (CCF) study is a French nationwide study including all consecutive adults with a diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection hospitalized in 24 centres between 26 February and 20 April 2020. Patients admitted directly to intensive care were excluded. Clinical, biological and imaging parameters were systematically collected at hospital admission. The primary outcome was in-hospital death.
Results: Of 2878 patients included (mean±SD age 66.6±17.0 years, 57.8% men), 360 (12.5%) died in the hospital setting, of which 7 (20.7%) were transferred to intensive care before death. The majority of patients had at least one (72.6%) or two (41.6%) cardiovascular risk factors, mostly hypertension (50.8%), obesity (30.3%), dyslipidaemia (28.0%) and diabetes (23.7%). In multivariable analysis, older age (hazard ratio [HR] 1.05, 95% confidence interval [CI] 1.03-1.06; P<0.001), male sex (HR 1.69, 95% CI 1.11-2.57; P=0.01), diabetes (HR 1.72, 95% CI 1.12-2.63; P=0.01), chronic kidney failure (HR 1.57, 95% CI 1.02-2.41; P=0.04), elevated troponin (HR 1.66, 95% CI 1.11-2.49; P=0.01), elevated B-type natriuretic peptide or N-terminal pro-B-type natriuretic peptide (HR 1.69, 95% CI 1.0004-2.86; P=0.049) and quick Sequential Organ Failure Assessment score ≥2 (HR 1.71, 95% CI 1.12-2.60; P=0.01) were independently associated with in-hospital death.
Conclusions: In this large nationwide cohort of patients hospitalized for COVID-19 in France, cardiovascular comorbidities and risk factors were associated with a substantial morbi-mortality burden.
(Copyright © 2021. Published by Elsevier Masson SAS.)
Databáze: MEDLINE
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