Inflammatory bowel disease in South-Eastern Norway III (IBSEN III): a new population-based inception cohort study from South-Eastern Norway.

Autor:	Kristensen VA; Department of Gastroenterology, Oslo University Hospital, Oslo, Norway.; Unger-Vetlesen Institute, Lovisenberg Diaconal Hospital, Oslo, Norway., Opheim R; Department of Gastroenterology, Oslo University Hospital, Oslo, Norway.; Department of Nursing Science, Institute of Health and Society, University of Oslo, Oslo, Norway., Perminow G; Pediatric Department, Oslo University Hospital, Oslo, Norway., Huppertz-Hauss G; Department of Gastroenterology, Telemark Hospital, Skien, Norway., Detlie TE; Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Lund C; Department of Gastroenterology, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Andersen S; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Paediatrics, Vestfold Hospital Trust, Tønsberg, Norway., Olsen BC; Department of Gastroenterology, Telemark Hospital, Skien, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Johansen I; Department of Health Sciences, Østfold University college, Halden, Norway., Medhus AW; Department of Gastroenterology, Oslo University Hospital, Oslo, Norway., Vatn S; Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Brackmann S; Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Olbjørn C; Department of Paediatric and Adolescent Medicine, Akershus University Hospital, Lørenskog, Norway., Rove J; Department of Paediatric and Adolescent Medicine, Akershus University Hospital, Lørenskog, Norway., Henriksen M; Department of Gastroenterology, Østfold Hospital Trust, Grålum, Norway., Løvlund EE; Department of Pediatric and Adolescent Medicine, Østfold Hospital Trust, Grålum, Norway., Bengtson MB; Medical Department, Vestfold Hospital Trust, Tønsberg, Norway., Aabrekk TB; Medical Department, Vestfold Hospital Trust, Tønsberg, Norway., Tønnessen T; Department of Gastroenterology, Drammen Hospital, Vestre Viken Hospital Trust, Drammen, Norway., Vikskjold FB; Department of Pediatric and Adolescent medicine, Drammen Hospital Vestre Viken Hospital Trust., Yassin H; Department of Pediatrics, Telemark Hospital, Skien, Norway., Frigstad SO; Department of Medicine, Baerum Hospital, Vestre Viken Hospital Trust, Gjettum, Norway., Hasund A; Department of Medicine, Sorlandet Hospital Kristiansand, Kristiansand, Norway., Høie O; Department of Internal Medicine, Sørlandet Sykehus Arendal, Arendal, Norway., Schmidt K; Department of Pediatric and Adolescent Medicine, Sørlandet Sykehus Arendal, Arendal, Norway., Cetinkaya RB; Department of Medicine, Diakonhjemmet Hospital, Oslo, Norway., Torp R; Medical Department, Innlandet Hospital Trust, Hamar, Norway., Skogestad E; Medical Department, Innlandet Hospital Trust, Lillehammer, Norway., Holm HK; Pediatric Department, Innlandet Hospital Trust, Lillehammer, Norway., Ahmad TR; Department of Medicine, Lovisenberg Diakonale Sykehus, Oslo, Norway., Hovde Ø; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Medicine, Innlandet Hospital Trust, Gjøvik, Norway., Ystrøm CM; Department of Medicine, Innlandet Hospital Trust, Elverum, Norway., Aballi B; Pediatric Department, Innlandet Hospital Trust, Elverum, Norway., Sagosen A; Department of Medicine, Kongsberg Hospital, Vestre Viken Hospital Trust, Kongsberg, Norway., Pedersen A; Department of Medicine, Kongsvinger Hospital, Kongsvinger, Norway., Dahler S; Department of Medicine, Notodden Hospital, Notodden, Norway., Pallenschat J; Department of Medicine, Sørlandet Hospital Flekkefjord, Flekkefjord, Norway., Ricanek P; Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway., Høivik ML; Department of Gastroenterology, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Jazyk:	angličtina
Zdroj:	Scandinavian journal of gastroenterology [Scand J Gastroenterol] 2021 Aug; Vol. 56 (8), pp. 899-905. Date of Electronic Publication: 2021 Jun 21.
DOI:	10.1080/00365521.2021.1922746
Abstrakt:	Background and Aim: Modern treatment strategies for inflammatory bowel disease (IBD) are postulated to change the natural disease course. Inception cohort studies are the gold standard for investigating such changes. We have initiated a new population-based inception cohort study; Inflammatory bowel disease in South Eastern Norway III (IBSEN III). In this article, we describe the study protocol and baseline characteristics of the cohort. Methods: IBSEN III is an ongoing, population-based observational inception cohort study with prospective follow-up. Adult and pediatric patients with suspected IBD in the South-Eastern Health Region of Norway (catchment area of 2.95 million inhabitants in 2017), during the 3-year period from 2017 to 2019, were eligible for inclusion. Comprehensive clinical, biochemical, endoscopic, demographic, and patient-reported data were collected at the time of diagnosis and throughout standardized follow-up. For a portion of the patients, extensive biological material was biobanked. Results: The study included 2168 patients, of whom 1779 were diagnosed with IBD (Crohn's disease: 626, ulcerative colitis: 1082, IBD unclassified: 71). In 124 patients, there were subtle findings indicative of, but not diagnostic for, IBD. The remaining 265 patients were classified as symptomatic non-IBD controls. Conclusion: We have included patients in a comprehensive population-based IBD cohort from a catchment population of 2.95 million, and a unique biobank with materials from newly diagnosed and treatment-naïve IBD patients and symptomatic non-IBD controls. We believe this cohort will add important knowledge about IBD in the years to come.
Databáze:	MEDLINE
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