Caregiver-Reported Burden in RE-KINECT: Data From a Prospective Real-World Tardive Dyskinesia Screening Study.

Autor:	Cutler AJ; Andrew J. Cutler, MD, SUNY Upstate Medical University, Syracuse, NY, USA., Caroff SN; Stanley N. Caroff, MD, Department of Psychiatry, Corporal Michael J. Crescenz Veterans Affairs Medical Center and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Tanner CM; Caroline M. Tanner, MD, PhD, Neurology, UCSF School of Medicine and San Francisco VA Health Care System, San Francisco, CA, USA., Shalhoub H; Huda Shalhoub, PhD, Evidera, Waltham, MA, USA., Lenderking WR; William R. Lenderking, PhD, Patient Centered Research, Evidera, Waltham, MA, USA., Pagé V; Véronique Pagé, MSc, Evidera, Montreal, Quebec, Canada., Franey E; Ericha Franey, PhD, Medical Affairs, Neurocrine Biosciences, Inc., San Diego, CA, USA., Yonan C; Chuck Yonan, PharmD, Medical Affairs, Neurocrine Biosciences, Inc., San Diego, CA, USA.
Jazyk:	angličtina
Zdroj:	Journal of the American Psychiatric Nurses Association [J Am Psychiatr Nurses Assoc] 2023 Sep-Oct; Vol. 29 (5), pp. 389-399. Date of Electronic Publication: 2021 Jun 22.
DOI:	10.1177/10783903211023565
Abstrakt:	Background: RE-KINECT (NCT03062033), a real-world study of possible tardive dyskinesia (TD) in antipsychotic-treated patients, included a questionnaire to assess the effects of patients' abnormal involuntary movements on caregivers. Aims: To capture the experiences of caregivers who assisted individuals with abnormal involuntary movements that were confirmed by clinicians as being consistent with TD. Methods: Qualified (nonpaid) caregivers were invited to complete a questionnaire that included the following: caregivers' sociodemographic characteristics, their perceptions about the impact of abnormal involuntary movements on patients, and the impact of these movements on themselves (caregivers). Results: Of the 41 participating caregivers, 25 (61.0%) were women, 20 (48.8%) were employed full time or part time, and 35 (85.4%) were family members or friends. Based on responses from caregivers who noticed patients' abnormal involuntary movements and were caring for individuals who also noticed those movements, 48.0% of patients had "a lot" of severity in ≥1 body region and 76.0% had abnormal involuntary movements in ≥2 regions. Caregiver ratings were significantly correlated with patient ratings (but not with clinician ratings) for maximum severity of abnormal involuntary movements and the number of affected regions (both p <.05). Based on their own judgments and perceptions, caregivers reported that the patient's movements had "some" or "a lot" of impact on their (caregiver's) ability to continue usual activities (50.0%), be productive (58.3%), socialize (55.6%), or take care of self (50.0%). Conclusions: Caregivers as well as patients are negatively affected by TD, and the impact of TD on caregivers' lives should be considered when determining treatment options.
Databáze:	MEDLINE
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