Telomere shortening in late-life depression: A potential marker of depression severity.

Autor: Mendes-Silva AP; Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada., Vieira ELM; Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada., Xavier G; Department of Morphology and Genetics, Federal University of São Paulo, São Paulo, São Paulo, Brazil.; LINC-Interdisciplinary Laboratory of Clinical Neurosciences, Federal University of São Paulo, São Paulo, São Paulo, Brazil., Barroso LSS; Graduate Program in Molecular Medicine, Federal University of Minas Gerais School of Medicine, Belo Horizonte, Minas Gerais, Brazil., Bertola L; Graduate Program in Molecular Medicine, Federal University of Minas Gerais School of Medicine, Belo Horizonte, Minas Gerais, Brazil., Martins EAR; Graduate Program in Molecular Medicine, Federal University of Minas Gerais School of Medicine, Belo Horizonte, Minas Gerais, Brazil., Brietzke EM; Department of Psychiatry, Queen's University School of Medicine, Kingston, Ontario, Canada.; Centre for Neuroscience Studies (CNS), Queen's University, Kingston, Ontario, Canada., Belangero SIN; Department of Morphology and Genetics, Federal University of São Paulo, São Paulo, São Paulo, Brazil.; LINC-Interdisciplinary Laboratory of Clinical Neurosciences, Federal University of São Paulo, São Paulo, São Paulo, Brazil., Diniz BS; Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada.; Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; UConn Center on Aging, University of Connecticut Health Center, Farmington, Connecticut, USA.; Department of Psychiatry, University of Connecticut Health Center, Farmington, Connecticut, USA.
Jazyk: angličtina
Zdroj: Brain and behavior [Brain Behav] 2021 Aug; Vol. 11 (8), pp. e2255. Date of Electronic Publication: 2021 Jun 21.
DOI: 10.1002/brb3.2255
Abstrakt: Objectives: Telomeres are structures at the extremity of chromosomes that prevents genomic instability, and its shortening seems to be a hallmark of cellular aging. Past studies have shown contradictory results of telomere length (TL) in major depression, and are a few studies in late-life depression (LLD). This explores the association between TL as a molecular marker of aging and diagnosis of LLD, the severity of depressive symptoms, and cognitive performance in older adults.
Methods/design: We included 78 older adults (45 with LLD and 33 nondepressed controls, according to DSM-V criteria), aged 60-90 years. TL was measured in leukocytes by a quantitative polymerase chain reaction, determining the relative ratio (T/S) between the telomere region copy number (T) and a single copy gene (S), using a relative standard curve.
Results: TL was significantly shorter in the LLD compared with control participants (p = .039). Comparing groups through the severity of depressive symptoms, we found a negative correlation with the severity of depressive symptoms (Hamilton Depression Rating Scale-21, r = -0.325, p = .004) and medical burden (r = -0.271, p = .038). There was no significant correlation between TL and cognitive performance (Mattis Dementia Rating Scale, r = 0.152, p = .21).
Conclusions: We found that older adults with LLD have shorter telomere than healthy controls, especially those with a more severe depressive episode. Our findings suggest that shorter TL can be a marker of the severity of depressive episodes in older adults and indicate that these individuals may be at higher risk of age-associated adverse outcomes linked to depression.
(© 2021 The Authors. Brain and Behavior published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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