Oncogenic human papillomavirus in breast cancer: molecular prevalence in a group of Congolese patients.

Autor:	Boumba ALM; Faculté des Sciences de la Santé, Université Marien NGOUABI, Brazzaville, Republic of the Congo.; Laboratoire d'Analyses Médicales, Hôpital Général de LOANDJILI, Pointe-Noire, Republic of the Congo.; Laboratoire de Biologie Moléculaire HDL, Polyclinique Marie Madeleine GOMBES, Pointe-Noire, Republic of the Congo., Malanda Mboungou Moudiongui D; Faculté des Sciences de la Santé, Université Marien NGOUABI, Brazzaville, Republic of the Congo.; Service de laboratoire d'Anatomie et cytopathologie, Centre Hospitalier et Universitaire de Brazzaville, Brazzaville, Republic of the Congo., Ngatali SFC; Faculté des Sciences de la Santé, Université Marien NGOUABI, Brazzaville, Republic of the Congo.; Laboratoire d'Analyses Médicales, Hôpital Général de LOANDJILI, Pointe-Noire, Republic of the Congo., Takale RP; Faculté des Sciences de la Santé, Université Marien NGOUABI, Brazzaville, Republic of the Congo., Moukassa D; Faculté des Sciences de la Santé, Université Marien NGOUABI, Brazzaville, Republic of the Congo., Peko JF; Faculté des Sciences de la Santé, Université Marien NGOUABI, Brazzaville, Republic of the Congo.; Service de laboratoire d'Anatomie et cytopathologie, Centre Hospitalier et Universitaire de Brazzaville, Brazzaville, Republic of the Congo.
Jazyk:	angličtina
Zdroj:	Access microbiology [Access Microbiol] 2021 Mar 23; Vol. 3 (3), pp. 000216. Date of Electronic Publication: 2021 Mar 23 (Print Publication: 2021).
DOI:	10.1099/acmi.0.000216
Abstrakt:	Background: Since the work of Band et al . in 1990 ( Proc. Natl. Acad. Sci. USA 87:463-467), several studies have suggested a possible link between the pathogenesis of breast cancer and viral infection. Infection with oncogenic HPV has been one of the viruses implicated in breast cancer cases worldwide. Objective: To investigate the presence of HPV DNA in archived paraffin-embedded breast cancer cases at the University Hospital of Brazzaville and to assess the association between viral HPV infections and clinicopathological features. Methods: A total of 40 formalin-fixed paraffin-embedded (FFPE) biopsies were retrospectively collected and available information was recorded. HPV detection and genotyping were performed by real-time PCR by GeneXpert technology (Cepheid, Sunnyvale, USA). Results: The mean age was 51.1±11.4 years (range 22-75 years; median was 47). Overall, HPV DNA was detected in six (15%) breast carcinoma samples. HPV-16, the most common genotype was identified in 83.7 % of all samples. HPV porting with clinicopathological features showed no significant difference ( P >0.05). However, a statistically significant difference was observed between HPV infection and SBR grade ( P =0.05). Conclusion: Our study described a high prevalence of HPV-HR in breast cancer cases in the Congolese woman. Future type case-control studies are necessary to better describe the potential role of HPV in the occurrence of breast cancer in Congo. Competing Interests: The authors declare that there are no conflicts of interest. (© 2021 The Authors.)
Databáze:	MEDLINE
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