Necrotizing infundibulo-hypophysitis: case-report and literature review.

Autor: Magalhães-Ribeiro C; Department of Neurosurgery, Centro Hospitalar de Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal., Furtado A; Department of Anatomic Pathology, Centro Hospitalar de Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal., Baggen Santos R; Department of Neurosurgery, Centro Hospitalar de Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal., Mascarenhas L; Department of Neurosurgery, Centro Hospitalar de Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal., Costa Correia S; Department of Endocrinology, Centro Hospitalar de Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal., Rocha G; Department of Endocrinology, Centro Hospitalar de Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal., Resende M; Department of Neurosurgery, Centro Hospitalar de Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal.
Jazyk: angličtina
Zdroj: British journal of neurosurgery [Br J Neurosurg] 2024 Jun; Vol. 38 (3), pp. 613-616. Date of Electronic Publication: 2021 Jun 21.
DOI: 10.1080/02688697.2021.1940857
Abstrakt: Purpose: We describe a rare case of histopathologic-proven necrotizing infundibulo-hypophysitis (NIH).
Clinical History: A 40-year-old female presented with coexistence of central diabetes insipidus and hypopituitarism. Imaging disclosed a thickened infundibulum and a diffusely enlarged pituitary mass with gadolinium rim enhancement pattern. Microsurgical endonasal transsphenoidal resection was performed. The presence of extensive liquefactive necrosis, surrounded by lymphoplasmocytic inflammatory infiltrate, allowed for the diagnosis of NIH. Follow-up cranial imaging 10 months after surgery showed no evidence of reappearance of the lesion. There was no progression to panhypopituitarism.
Conclusion: Surgery and histopathological confirmation are the key diagnostic feature in NIH. The current case is the fifth report of NIH and the first one with an indolent course and without progression to panhypopituitarism so far.
Databáze: MEDLINE
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