Structure based design, synthesis, and evaluation of anti-CML activity of the quinolinequinones as LY83583 analogs.
Autor: | Bayrak N; Department of Chemistry, Faculty of Engineering, Istanbul University-Cerrahpasa, Avcilar, Istanbul, Turkey., Ciftci HI; Department of Drug Discovery, Science Farm Ltd., Kumamoto, Japan; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, School of Pharmacy, Kumamoto University, Kumamoto, Japan., Yıldız M; Chemistry Department, Gebze Technical University, Gebze, Kocaeli, Turkey., Yıldırım H; Department of Chemistry, Faculty of Engineering, Istanbul University-Cerrahpasa, Avcilar, Istanbul, Turkey., Sever B; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, School of Pharmacy, Kumamoto University, Kumamoto, Japan; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskisehir, Turkey., Tateishi H; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, School of Pharmacy, Kumamoto University, Kumamoto, Japan., Otsuka M; Department of Drug Discovery, Science Farm Ltd., Kumamoto, Japan; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, School of Pharmacy, Kumamoto University, Kumamoto, Japan., Fujita M; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, School of Pharmacy, Kumamoto University, Kumamoto, Japan. Electronic address: mfujita@kumammot-u.ac.jp., Tuyun AF; Department of Chemistry, Faculty of Science, Istanbul University, Fatih, Istanbul, Turkey. Electronic address: aftuyun@gmail.com. |
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Jazyk: | angličtina |
Zdroj: | Chemico-biological interactions [Chem Biol Interact] 2021 Aug 25; Vol. 345, pp. 109555. Date of Electronic Publication: 2021 Jun 16. |
DOI: | 10.1016/j.cbi.2021.109555 |
Abstrakt: | Quinone-based small molecules are the promising structures for antiproliferative drug design and can induce apoptosis in cancer cells. Among them, one of the quinolinequinones, named as 6-anilino-5,8-quinolinequinone, LY83583 has the ability to inhibit the growth of cancer cells as an inhibitor of cyclase. The biological potential of all synthesized compounds as the analogs of the identified lead molecule LY83583 that possessed the antiproliferative efficiency was determined. The two series of the LY83583 analogs containing electron-withdrawing or electron-donating group(s) were synthesized and subsequently in vitro evaluated for their cytotoxic activity against K562, Jurkat, MT-2, and HeLa cell lines using MTT assay. All the LY83583 analogs showed antiproliferative activity with good IC (Copyright © 2021 Elsevier B.V. All rights reserved.) |
Databáze: | MEDLINE |
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