Impaired T-Lymphocyte Responses During Childhood Staphylococcus aureus Infection.

Autor:	Li Z; Center for Microbial Pathogenesis, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA., Beesetty P; Center for Microbial Pathogenesis, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA.; Present affiliation: Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada., Gerges G; Center for Microbial Pathogenesis, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA.; Present affiliation: College of Medicine, The Ohio State University, Columbus, OH, USA., Kleinhenz M; Center for Microbial Pathogenesis, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA., Moore-Clingenpeel M; Biostatistics Resource, Nationwide Children's Hospital, Columbus, Ohio, USA., Yang C; Center for Microbial Pathogenesis, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA.; Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA., Ahmed LB; Center for Microbial Pathogenesis, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA.; Present affiliation: College of Public Health, The Ohio State University, Columbus OH, USA., Hensley J; Division of Critical Care Medicine, Nationwide Children's Hospital, Columbus, Ohio, USA., Steele L; Division of Critical Care Medicine, Nationwide Children's Hospital, Columbus, Ohio, USA., Chong AS; Department of Surgery, University of Chicago, Chicago, Illinois, USA., Montgomery CP; Center for Microbial Pathogenesis, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA.; Division of Critical Care Medicine, Nationwide Children's Hospital, Columbus, Ohio, USA.; Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, Ohio, USA.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2022 Jan 05; Vol. 225 (1), pp. 177-185.
DOI:	10.1093/infdis/jiab326
Abstrakt:	Background: Staphylococcus aureus infections are common throughout the lifespan, with recurrent infections occurring in nearly half of infected children. There is no licensed vaccine, underscoring the need to better understand how S. aureus evades protective immunity. Despite much study, the relative contributions of antibodies and T cells to protection against S. aureus infections in humans are not fully understood. Methods: We prospectively quantified S. aureus-specific antibody levels by ELISA and T-cell responses by ELISpot in S. aureus-infected and healthy children. Results: S. aureus-specific antibody levels and T-cell responses increased with age in healthy children, suggesting a coordinated development of anti-staphylococcal immunity. Antibody levels against leukotoxin E (LukE) and Panton-Valentine leukocidin (LukS-PV), but not α-hemolysin (Hla), were higher in younger infected children, compared with healthy children; these differences disappeared in older children. We observed a striking impairment of global and S. aureus-specific T-cell function in children with invasive and noninvasive infection, suggesting that S. aureus-specific immune responses are dysregulated during childhood infection regardless of the infection phenotype. Conclusions: These findings identify a potential mechanism by which S. aureus infection actively evades adaptive immune responses, thereby preventing the development of protective immunity and maintaining susceptibility to recurrent infection. (© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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