Prolonged overall treatment time negatively affects the outcomes of stereotactic body radiotherapy for early-stage non-small-cell lung cancer: A propensity score-weighted, single-center analysis.

Autor: Ikawa T; Department of Radiation Oncology, Osaka International Cancer Institute, Osaka, Japan., Tabuchi T; Cancer Control Center, Osaka International Cancer Institute, Osaka, Japan., Konishi K; Department of Radiation Oncology, Osaka International Cancer Institute, Osaka, Japan., Morimoto M; Department of Radiation Oncology, Osaka International Cancer Institute, Osaka, Japan., Hirata T; Department of Radiation Oncology, Osaka International Cancer Institute, Osaka, Japan.; Department of Radiation Oncology, Osaka University Graduate School of Medicine, Osaka, Japan., Kanayama N; Department of Radiation Oncology, Osaka International Cancer Institute, Osaka, Japan., Wada K; Department of Radiation Oncology, Osaka International Cancer Institute, Osaka, Japan., Toratani M; Department of Radiation Oncology, Osaka International Cancer Institute, Osaka, Japan., Okawa S; Cancer Control Center, Osaka International Cancer Institute, Osaka, Japan., Ogawa K; Department of Radiation Oncology, Osaka University Graduate School of Medicine, Osaka, Japan., Teshima T; Department of Radiation Oncology, Osaka International Cancer Institute, Osaka, Japan.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2021 Jun 18; Vol. 16 (6), pp. e0253203. Date of Electronic Publication: 2021 Jun 18 (Print Publication: 2021).
DOI: 10.1371/journal.pone.0253203
Abstrakt: Previous studies have reported conflicting results for the effect of overall treatment time with stereotactic body radiotherapy on tumor control in early-stage non-small-cell lung cancer. To examine this effect, we conducted a propensity score-weighted, retrospective, observational study at a single institution. We analyzed the data of 200 patients with early-stage non-small-cell lung cancer who underwent stereotactic body radiotherapy (48 Gy in 4 fractions) at our institution between January 2007 and October 2013. Patients were grouped into consecutive (overall treatment time = 4-5 days, n = 116) or non-consecutive treatment groups (overall treatment time = 6-10 days, n = 84). The outcomes of interest were local control and overall survival. The Cox regression model was used with propensity score and inverse probability of treatment weighting. The median overall treatment times in the consecutive and non-consecutive groups were 4 and 6 days, respectively. The 5-year local control and overall survival rates in the consecutive vs. the non-consecutive group were 86.3 vs. 77.2% and 55.5 vs. 51.8%, respectively. After propensity score weighting, consecutive stereotactic body radiotherapy was associated with positive local control (adjusted hazard ratio 0.30, 95% confidence interval 0.14-0.65; p = 0.002) and overall survival (adjusted hazard ratio 0.56, 95% confidence interval 0.34-0.91; p = 0.019) benefits. The prolonged overall treatment time of stereotactic body radiotherapy treatment negatively affected the outcomes of patients with early-stage non-small-cell lung cancer. To our knowledge, this is the first study to show that in patients with early-stage non-small-cell lung cancer treated with the same dose-fractionation regimen, consecutive stereotactic body radiotherapy has a more beneficial effect on tumor control than non-consecutive stereotactic body radiotherapy.
Competing Interests: “Toshiki Ikawa and Naoyuki Kanayama have served as consultants for Varian Medical Systems and may receive an honorarium from Varian Medical Systems. This does not alter our adherence to PLOS ONE policies on sharing data and materials. The other authors declare no competing interests.”
Databáze: MEDLINE
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