Mesothelin is Commonly Expressed in Pancreatic Adenocarcinoma but Unrelated to Cancer Aggressiveness.

Autor: Weidemann S; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Perez D; General, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Izbicki JR; General, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Neipp M; General, Vascular and Visceral Surgery Clinic, Itzehoe Medical Center, Itzehoe, Germany., Mofid H; General, Visceral Thoracic and Vascular Surgery Clinic, Regio Clinic Pinneberg, Pinneberg, Germany., Daniels T; General, Visceral and Tumor Surgery Clinic, Albertinen Hospital, Hamburg, Germany., Nahrstedt U; Department of General and Abdominal Surgery, Schoen Clinic Hamburg Eilbek, Hamburg, Germany., Jacobsen F; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Bernreuther C; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Simon R; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Steurer S; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Burandt E; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Marx AH; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Department of Pathology, Academic Hospital Fuerth, Fuerth, Germany., Krech T; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Institute of Pathology, Clinical Center Osnabrueck, Osnabrueck, Germany., Clauditz TS; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Jansen K; General, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Jazyk: angličtina
Zdroj: Cancer investigation [Cancer Invest] 2021 Oct; Vol. 39 (9), pp. 711-720. Date of Electronic Publication: 2021 Aug 18.
DOI: 10.1080/07357907.2021.1943747
Abstrakt: Data on Mesothelin (MSLN) expression in human normal and cancerous tissues is controversial. We employed immunohistochemistry (IHC) on a tissue microarray (TMA) from 599 pancreatic cancers and 12 large tissue sections of pancreatitis. MSLN expression was highest in pancreatic adenocarcinomas (89%) and adenocarcinomas of the ampulla Vateri (79%), infrequent in pancreatitis and absent in 6 acinus cell carcinomas and normal pancreas. MSLN expression was unrelated to pathological tumor stage, grade, metastasis, and tumor-infiltrating CD8+ lymphocytes. In conclusion, pancreatic cancer may be ideally suited for putative anti- MSLN therapies, and MSLN may represent a suitable biomarker for pancreatic cancer diagnosis, especially on small biopsies.
Databáze: MEDLINE