Mentha aquatica L. aerial parts: in vitro anti-proliferative evaluation on human tumour and non-tumour cell lines.

Autor:	de Souza LB; Chemical, Biological and Agricultural Pluridisciplinary Research Center (CPQBA), University of Campinas - UNICAMP, Paulínia, Brazil.; Postgraduate Program in Dentistry, Piracicaba Dental School, FOP, University of Campinas - UNICAMP, Piracicaba, Brazil., Tinti SV; Chemical, Biological and Agricultural Pluridisciplinary Research Center (CPQBA), University of Campinas - UNICAMP, Paulínia, Brazil., Sousa IMO; Medical Science Department, FCM, University of Campinas - UNICAMP, Campinas, Brazil., Montanari I Jr; Chemical, Biological and Agricultural Pluridisciplinary Research Center (CPQBA), University of Campinas - UNICAMP, Paulínia, Brazil., da Costa JL; LTA, Faculty of Pharmaceutical Sciences, FCF, University of Campinas - UNICAMP, Campinas, Brazil., de Carvalho JE; LAFTEx, Faculty of Pharmaceutical Sciences, FCF, University of Campinas - UNICAMP, Campinas, Brazil., Foglio MA; LAFTEx, Faculty of Pharmaceutical Sciences, FCF, University of Campinas - UNICAMP, Campinas, Brazil., Ruiz ALTG; LAFTEx, Faculty of Pharmaceutical Sciences, FCF, University of Campinas - UNICAMP, Campinas, Brazil.
Jazyk:	angličtina
Zdroj:	Natural product research [Nat Prod Res] 2022 Jun; Vol. 36 (12), pp. 3117-3123. Date of Electronic Publication: 2021 Jun 18.
DOI:	10.1080/14786419.2021.1937152
Abstrakt:	Bearing in mind the several medicinal properties of Mentha genus, this work aimed to evaluate the anti-proliferative potential of the ethanolic extract (EE) and fractions from M. aquatica L aerial parts. Using the anti-proliferative protocol developed by the NCI/USA, four fractions (F2 - F4 and F6) obtained from EE showed promising anti-proliferative profile against a panel of human tumor and non-tumor cell lines. After 24-h exposure, F2 (0.25 µg/mL) showed potent and irreversible anti-proliferative effect without inducing cell cycle arrest in both NCI-H460 and MCF-7 cells, without (anti) estrogenic activity. These effects were lost after storage of F2 diluted in dimethyl sulfoxide at -80 °C during 2 weeks. Analysis by gas chromatography coupled to mass detection evidenced some chemical changes induced by F2 storage in solution. The present study demonstrated the anti-proliferative effect of M. aquatica . Further studies are necessary to determine better storage conditions to enhance F2 stability.
Databáze:	MEDLINE
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