Use of Statins Among Patients Taking Levothyroxine: an Observational Drug Utilization Study Across Sites.

Autor:	Idrees T; Section of Adult and Pediatric Endocrinology and Metabolism, University of Chicago, Chicago, IL 60637, USA., Prieto WH; Fleury Group, Sao Paulo, SP 04344, Brazil., Casula S; Department of Endocrinology, Miami Veterans Affairs Healthcare System, Miami, FL 33136, USA.; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33125, USA., Ajith A; Center for Research Informatics, University of Chicago, Chicago, IL 60637, USA., Ettleson M; Section of Adult and Pediatric Endocrinology and Metabolism, University of Chicago, Chicago, IL 60637, USA., Narchi FAA; Biolab Pharmaceutical, Sao Paulo, SP 04538, Brazil., Russo PST; Fleury Group, Sao Paulo, SP 04344, Brazil., Fernandes F; Biolab Pharmaceutical, Sao Paulo, SP 04538, Brazil., Johnson J; Center for Research Informatics, University of Chicago, Chicago, IL 60637, USA., Mayampurath A; Department of Pediatrics, University of Chicago, Chicago, IL 60637, USA., Maciel RMB; Fleury Group, Sao Paulo, SP 04344, Brazil.; Federal University of Sao Paulo, Sao Paulo, SP 04039, Brazil., Bianco AC; Section of Adult and Pediatric Endocrinology and Metabolism, University of Chicago, Chicago, IL 60637, USA.
Jazyk:	angličtina
Zdroj:	Journal of the Endocrine Society [J Endocr Soc] 2021 Mar 06; Vol. 5 (7), pp. bvab038. Date of Electronic Publication: 2021 Mar 06 (Print Publication: 2021).
DOI:	10.1210/jendso/bvab038
Abstrakt:	Context: Treatment with levothyroxine (LT4) that normalize serum thyrotropin (TSH) is expected to restore lipid metabolism. Objective: To assess statin utilization in LT4-treated patients through an observational drug utilization study. Methods: Three sites were involved: (1) 10 723 outpatients placed on LT4 during 2006-2019 identified from the Clinical Research Data Warehouse of the University of Chicago; (2) ~1.4 million LT4 prescriptions prepared by primary care physicians during January-December 2018, identified from the IQVIA™ database of medical prescriptions in Brazil; (30 ~5.4 million patient interviews during 2009-2019, including ~0.32 million patients on LT4, identified from the Fleury Group database in Brazil. Results: On site 1, initiation of therapy with LT4 increased the frequency of statin utilization (19.1% vs 24.6%), which occurred ~1.5 years later (median 76 weeks) and, among those patients that were on statins, increased intensity of treatment by 33%, despite normalization of serum TSH levels; on site 2, after matching for sex and age, the frequency of statins prescription was higher for those patients using LT4: females, 2.1 vs 3.4% (odds ratio [OR] 1.656 [1.639-1.673]); males, 3.1 vs 4.4% (OR 1.435 [1.409-1.462]); and, on site 3, after matching for sex and age, the frequency of statin utilization was higher in those patients using LT4: females, 10 vs 18% (OR 2.02 [2.00-2.04]); males, 15 vs 25% (OR 1.92 [1.88-1.96]); all P values were <.0001. Conclusion: Prescription and utilization of statins were higher in patients taking LT4. The reasons for this association should be addressed in future studies. (© The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society.)
Databáze:	MEDLINE
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