Rapid custom prototyping of soft poroelastic biosensor for simultaneous epicardial recording and imaging.

Autor: Kim B; School of Mechanical Engineering, Purdue University, West Lafayette, IN, USA., Soepriatna AH; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA., Park W; School of Mechanical Engineering, Purdue University, West Lafayette, IN, USA., Moon H; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA., Cox A; Department of Comparative Pathobiology, Purdue College of Veterinary Medicine, West Lafayette, IN, USA., Zhao J; Chemical Diagnostics and Engineering, Los Alamos National Laboratory, Los Alamos, NM, USA., Gupta NS; Chemical Diagnostics and Engineering, Los Alamos National Laboratory, Los Alamos, NM, USA., Park CH; Chemical Diagnostics and Engineering, Los Alamos National Laboratory, Los Alamos, NM, USA.; Department of Energy Engineering, Gyeongnam National University of Science and Technology, Jinju-Si, Republic of Korea., Kim K; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA., Jeon Y; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.; School of Mechanical Engineering, Hanyang University, Seoul, Republic of Korea., Jang H; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.; School of Mechanical Engineering, Hanyang University, Seoul, Republic of Korea., Kim DR; School of Mechanical Engineering, Hanyang University, Seoul, Republic of Korea., Lee H; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA., Lee KS; Chemical Diagnostics and Engineering, Los Alamos National Laboratory, Los Alamos, NM, USA. kslee@lanl.gov., Goergen CJ; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA. cgoergen@purdue.edu., Lee CH; School of Mechanical Engineering, Purdue University, West Lafayette, IN, USA. lee2270@purdue.edu.; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA. lee2270@purdue.edu.; Department of Materials Engineering, Purdue University, West Lafayette, IN, USA. lee2270@purdue.edu.; Birck Nanotechnology Center, Purdue University, West Lafayette, IN, USA. lee2270@purdue.edu.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2021 Jun 17; Vol. 12 (1), pp. 3710. Date of Electronic Publication: 2021 Jun 17.
DOI: 10.1038/s41467-021-23959-3
Abstrakt: The growing need for the implementation of stretchable biosensors in the body has driven rapid prototyping schemes through the direct ink writing of multidimensional functional architectures. Recent approaches employ biocompatible inks that are dispensable through an automated nozzle injection system. However, their application in medical practices remains challenged in reliable recording due to their viscoelastic nature that yields mechanical and electrical hysteresis under periodic large strains. Herein, we report sponge-like poroelastic silicone composites adaptable for high-precision direct writing of custom-designed stretchable biosensors, which are soft and insensitive to strains. Their unique structural properties yield a robust coupling to living tissues, enabling high-fidelity recording of spatiotemporal electrophysiological activity and real-time ultrasound imaging for visual feedback. In vivo evaluations of custom-fit biosensors in a murine acute myocardial infarction model demonstrate a potential clinical utility in the simultaneous intraoperative recording and imaging on the epicardium, which may guide definitive surgical treatments.
Databáze: MEDLINE
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