An overview of the synaptic vesicle lipid composition.

Autor: Binotti B; Department of Biochemistry, University of Würzburg, Am Hubland, 97074, Würzburg, Germany., Jahn R; Department of Neurobiology, Max-Planck-Institute for Biophysical Chemistry, Am Faßberg 11, 37077, Göttingen, Germany. Electronic address: rjahn@gwdg.de., Pérez-Lara Á; Department of Physical Chemistry, University of Granada, Campus Universitario de Cartuja, 18071, Granada, Spain. Electronic address: fperezl@ugr.es.
Jazyk: angličtina
Zdroj: Archives of biochemistry and biophysics [Arch Biochem Biophys] 2021 Sep 30; Vol. 709, pp. 108966. Date of Electronic Publication: 2021 Jun 15.
DOI: 10.1016/j.abb.2021.108966
Abstrakt: Chemical neurotransmission is the major mechanism of neuronal communication. Neurotransmitters are released from secretory organelles, the synaptic vesicles (SVs) via exocytosis into the synaptic cleft. Fusion of SVs with the presynaptic plasma membrane is balanced by endocytosis, thus maintaining the presynaptic membrane at steady-state levels. The protein machineries responsible for exo- and endocytosis have been extensively investigated. In contrast, less is known about the role of lipids in synaptic transmission and how the lipid composition of SVs is affected by dynamic exo-endocytotic cycling. Here we summarize the current knowledge about the composition, organization, and function of SV membrane lipids. We also cover lipid biogenesis and maintenance during the synaptic vesicle cycle.
(Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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